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    ANALYSIS DEVICE
    1.
    发明公开
    ANALYSIS DEVICE 有权
    分析装置

    公开(公告)号：EP2543994A1

    公开(公告)日：2013-01-09

    申请号：EP11750293.0

    申请日：2011-01-14

    申请人： Hitachi High-Technologies Corporation

    发明人： NOGAMI, Makoto ,  KANDA, Katsuhiro ,  ITO, Shinya

    IPC分类号： G01N27/62 ,  G01N1/10 ,  G01N1/28 ,  G01N1/34

    CPC分类号： G01N35/0098 ,  G01N1/405 ,  G01N35/025 ,  G01N2035/1053

    摘要： Disclosed is an analysis device which can analyze substances with low blood concentration with high precision without having to make the device larger. The analysis device is composed of: a specimen disk equipped with specimen containers; a reagent disk equipped with reagent containers; a first disk equipped with first containers where purification of the subject component to be measured in the specimen is carried out; a second disk equipped with second containers where purification of the sample purified in the first container is carried out; and a mass spectrometry unit which measures the specimen purified in the second container.

    摘要翻译： 本发明公开了一种分析装置，其可以高精度地分析血液浓度低的物质，而不必增大装置。 分析装置由以下部分组成：装有样本容器的样本盘; 装有试剂容器的试剂盘; 配备有第一容器的第一盘，在该第一容器中进行样本中待测量的对象成分的净化; 装备有第二容器的第二盘，其中进行在第一容器中纯化的样品的纯化; 以及质量分析单元，其测量在第二容器中净化的样本。

    COMPONENTIAL ANALYZER, DRUG EFFICACY ANALYZER, AND ANALYSIS METHOD
    2.
    发明公开
    COMPONENTIAL ANALYZER, DRUG EFFICACY ANALYZER, AND ANALYSIS METHOD 审中-公开
    成分分析仪，药物有效性分析仪和分析方法

    公开(公告)号：EP3272852A1

    公开(公告)日：2018-01-24

    申请号：EP17186423.4

    申请日：2014-11-26

    申请人： Hitachi High-Technologies Corporation

    发明人： TAKAHASHI, Ryosuke ,  KANDA, Katsuhiro ,  SHIMIZU, Yusuke ,  ICHIKAWA, Hisashi

    IPC分类号： C12M1/34 ,  C12M1/00 ,  G01N33/15 ,  G01N33/50

    摘要： Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the hepatocyte cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy. The object of the present invention is to provide an apparatus and method for understanding a total picture of pharmacokinetics in vitro by quantifying a fraction of basolateral (Basal/Basolateral) efflux, a fraction of lumen (Apical)-side excretion, and a fraction remaining in a cell of a drug which has been administered to the cell to determine the distribution ratio of each fraction.

    摘要翻译： 本发明的应用使得能够量化候选药物化合物（母体化合物及其代谢物）的部分，其中一部分通过转运蛋白和通过扩散而排泄至基底外侧（基底/基底外侧）侧，一个排泄至内腔（顶端）侧 ，一个留在肝细胞中。 这使得能够确定施用的候选药物化合物的总量以及这些级分的分配比例。 可以评估施用的候选药物化合物的动力学，由此能够体外筛选显示功效的候选药物的大量候选药物化合物。 本发明的目的是提供一种用于通过定量分析基底外侧（基底/基底外侧）外排，内腔部分（顶端）侧排泄和剩余部分的分数来理解体外药代动力学总图的装置和方法 在已经给予细胞的药物的细胞中以确定每个部分的分配比率。

    ADSORBENT AND METHOD FOR PRODUCING SAME
    3.
    发明公开
    ADSORBENT AND METHOD FOR PRODUCING SAME 审中-公开
    SAUGFÄHIGERARTIKEL UND VERFAHREN ZU SEINER HERSTELLUNG

    公开(公告)号：EP2564923A1

    公开(公告)日：2013-03-06

    申请号：EP11775110.7

    申请日：2011-04-28

    申请人： Hitachi High-Technologies Corporation

    发明人： NUNOSHIGE, Jun ,  KAGAWA, Hiroyuki ,  ITO, Shinya ,  KANDA, Katsuhiro ,  WAKI, Izumi ,  ARAYA, Kotaro ,  TAMURA, Terumi

    IPC分类号： B01J20/281 ,  G01N30/88

    CPC分类号： B01J20/285 ,  B01J2220/62 ,  B01J2220/82 ,  G01N30/7233

    摘要： An adsorbent that enables solid phase extraction with high efficiency and good selectivity of solutes having a broad chromatographic polarity range including high-polarity solute molecules while suppressing adsorption of impurities, and a solid phase extraction method therefor are provided. A heterocyclic-ring-containing copolymer adsorbent that is provided herein comprises a copolymer that comprises: a multifunctional heterocyclic-ring-containing monomer having a heterocyclic ring containing at least two heteroatoms in the ring system; and a monomer that is copolymerizable with the multifunctional heterocyclic-ring-containing monomer, wherein the multifunctional heterocyclic ring constitutes the main chain structure. Furthermore, the solid phase extraction method comprises a step of bringing a solution containing any one of a low-polarity solute molecule, a moderate-polarity solute molecule, and a high-polarity solute molecule as a solute into contact with the heterocyclic-ring-containing copolymer adsorbent, so that one or more types of solute are selectively adsorbed and held.

    摘要翻译： 提供一种吸附剂，其能够高效率地进行固相萃取，并且具有宽的色谱极性范围的溶质的选择性，包​​括高极性溶质分子同时抑制杂质的吸附，以及其固相萃取方法。 本文提供的含杂环共聚物吸附剂包括共聚物，其包含：具有在环系中含有至少两个杂原子的杂环的多官能含杂环单体; 和可与含多官能杂环的单体共聚的单体，其中多官能杂环构成主链结构。 此外，固相萃取方法包括使含有低极性溶质分子，中等极性溶质分子和高极性溶质分子中的任一种的溶液作为溶质与杂环 - 含有共聚物吸附剂，使得一种或多种类型的溶质被选择性吸附和保持。

    ANALYSIS DEVICE
    4.
    发明授权
    ANALYSIS DEVICE 有权

    公开(公告)号：EP2543994B1

    公开(公告)日：2018-11-14

    申请号：EP11750293.0

    申请日：2011-01-14

    申请人： Hitachi High-Technologies Corporation

    发明人： NOGAMI, Makoto ,  KANDA, Katsuhiro ,  ITO, Shinya

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N1/40

    CPC分类号： G01N35/0098 ,  G01N1/405 ,  G01N35/025 ,  G01N2035/1053

    摘要： Disclosed is an analysis device which can analyze substances with low blood concentration with high precision without having to make the device larger. The analysis device is composed of: a specimen disk equipped with specimen containers; a reagent disk equipped with reagent containers; a first disk equipped with first containers where purification of the subject component to be measured in the specimen is carried out; a second disk equipped with second containers where purification of the sample purified in the first container is carried out; and a mass spectrometry unit which measures the specimen purified in the second container.