公开(公告)号：EP3077519A1

公开(公告)日：2016-10-12

申请号：EP14820762.4

申请日：2014-12-03

申请人： Hookipa Biotech AG

发明人： ORLINGER, Klaus ,  LINGNAU, Karen ,  MONATH, Thomas ,  GUIRAKHOO, Farshad ,  FUHRMANN, Gerhard ,  COHEN, Katherine ,  BAUMGARTL-STRASSER, Vera ,  ASPÖCK, Andreas ,  KAINER, Manuela ,  BRIM, Bernhard ,  KIEFMANN, Bettina ,  WATSON, Elizabeth ,  AISTLEITHNER, Mario ,  BAYER, Katharina ,  MÜHLBACHER, Elsa

IPC分类号： C12N15/86 ,  A61K39/245 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/55566 ,  C07K14/005 ,  C07K16/10 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16134 ,  C12N2760/10021 ,  C12N2760/10043 ,  C12N2840/20 ,  C12N2840/206

摘要： Provided herein are genetically modified arenaviral vectors suitable as vaccines for prevention and treatment of cytomegalovirus infections and reactivation. Also provided herein are pharmaceutical compositions and methods for the treatment of cytomegalovirus infections and reactivation. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of treating cytomegalovirus infections and reactivation.

摘要翻译： 本文提供了适合作为预防和治疗巨细胞病毒感染和再激活的疫苗的遗传修饰的斑马鱼病毒载体。 本文还提供了用于治疗巨细胞病毒感染和再激活的药物组合物和方法。 具体地，本文提供了药物组合物，疫苗和治疗巨细胞病毒感染和再激活的方法。

公开(公告)号：EP3373959A1

公开(公告)日：2018-09-19

申请号：EP16797775.0

申请日：2016-11-04

申请人： Hookipa Biotech AG

发明人： SCHMIDT, Sarah ,  ORLINGER, Klaus ,  COHEN, Katherine

IPC分类号： A61K39/00

CPC分类号： A61K39/001117 ,  A61K39/0011 ,  A61K39/001135 ,  A61K39/001149 ,  A61K39/12 ,  A61K2039/5256 ,  A61P35/00 ,  C12N15/62

摘要： The present application relates generally to genetically modified arenaviruses that are suitable vaccines against neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for vaccines and/or treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus in combination with an immune checkpoint inhibitor, wherein the arenavirus has been engineered to include a nucleotide sequence encoding a tumor antigen, tumor associated antigen or antigenic fragment thereof.

公开(公告)号：EP3371316A1

公开(公告)日：2018-09-12

申请号：EP16791573.5

申请日：2016-11-03

申请人： Hookipa Biotech AG

发明人： MONATH, Thomas ,  COHEN, Katherine ,  BAUMGARTL-STRASSER, Vera

IPC分类号： C12N15/86 ,  A61K39/29 ,  C12N15/36 ,  C12N15/62

CPC分类号： C07K14/005 ,  A61K9/0019 ,  A61K39/292 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/575 ,  A61P31/20 ,  C07K2319/00 ,  C12N15/86 ,  C12N2730/10134 ,  C12N2760/10022 ,  C12N2760/10043

摘要： The present application provides immunotherapies for Hepatitis B virus infections. Provided herein are genetically modified arenaviral vectors suitable as vaccines for prevention and treatment of Hepatitis B virus infections. Also provided herein are pharmaceutical compositions and methods for the treatment of Hepatitis B virus infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of treating Hepatitis B virus infection.

公开(公告)号：EP3307308A2

公开(公告)日：2018-04-18

申请号：EP16730302.3

申请日：2016-06-09

申请人： Hookipa Biotech AG

发明人： ORLINGER, Klaus ,  MONATH, Thomas ,  LILJA, Anders ,  SCHMIDT, Sarah ,  BERKA, Ursula ,  SCHWENDINGER, Michael ,  WATSON, Elizabeth ,  KIEFMANN, Bettina ,  HINTERAMSKOGLER, Julia ,  FUHRMANN, Gerhard ,  ASPÖCK, Andreas ,  COHEN, Katherine

IPC分类号： A61K39/12 ,  C07K14/005 ,  C07K14/025

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5256 ,  A61P35/00 ,  C07K14/025 ,  C12N2710/20034 ,  C12N2760/10043 ,  C12N2760/10051 ,  Y02A50/467

摘要： Provided herein are genetically modified arenaviruses suitable as vaccines against neoplastic diseases or cancer. The invention also relates to pharmaceutical compositions and methods for the prevention or treatment of certain infections causing neoplastic diseases or cancer, such as infections with oncogenic viruses. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing or treating diseases and conditions caused by and associated with infections with Human Papillomavirus (HPV), such as cervical cancer, anogenital cancer, head and neck cancer and skin cancers. Also provided herein are immunotherapies for the treatment of a neoplastic disease, such as a neoplastic disease caused by infection with oncogenic viruses.