专利检索 ap:("Hovione Scientia Limited") AND inv:"Fernandez Casares, Ana" 第 1 页

1.

发明公开
NEW POLYMORPHIC FORMS OF MINOCYCLINE BASE AND PROCESSES FOR THEIR PREPARATION 审中-公开

公开(公告)号：EP3354637A1

公开(公告)日：2018-08-01

申请号：EP18155320.7

申请日：2016-02-12

申请人： Hovione Scientia Limited

发明人： Mendes, Zita , Cacela, Constança , Ten Figas, Gloria , Fernandez Casares, Ana

IPC分类号： C07C237/26

CPC分类号： C07C237/26 , A61K31/65 , C07B2200/13

摘要： The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.