公开(公告)号：EP1255869A1

公开(公告)日：2002-11-13

申请号：EP01916067.0

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  BARASH, Steven, C. ,  RUBEN, Steven, M. ,  BRISE, Charles, E

IPC分类号： C12Q1/68 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  A61K38/00 ,  C07K1/00 ,  C07H21/04

CPC分类号： A61K38/00 ,  C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06 ,  C12Q1/68

摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifiying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及新蛋白质。 更具体而言，提供了编码新多肽的分离的核酸分子。 提供了与这些多肽结合的新多肽和抗体。 还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。