公开(公告)号：EP3074050A4

公开(公告)日：2017-11-29

申请号：EP14857152

申请日：2014-10-28

申请人： ICAHN SCHOOL MED MOUNT SINAI ,  UNIV ROCKEFELLER

发明人： SCHAEFER ANNE ,  GREENGARD PAUL

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P25/08

CPC分类号： C12N15/113 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/185 ,  A61K49/0008 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515 ,  C12N2310/3521 ,  G01N33/5058

摘要： The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.

公开(公告)号：EP2265730A4

公开(公告)日：2012-03-21

申请号：EP09719684

申请日：2009-03-12

申请人： UNIV ROCKEFELLER

发明人： HEINTZ NATHANIEL ,  GREENGARD PAUL ,  HEIMAN MYRIAM ,  SCHAEFER ANNE ,  DOYLE JOSEPH P N ,  DOUGHERTY JOSEPH D

IPC分类号： C12Q1/68 ,  C12N15/11 ,  G01N33/50

CPC分类号： C12N15/62 ,  A01K67/0278 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/01 ,  C12N15/111 ,  C12N2320/12 ,  G01N33/5023 ,  G01N33/5058 ,  G01N2800/285

摘要： Methods and compositions are provided for translational profiling and molecular phenotyping of specific tissues, cells and cell subtypes of interest. The methods provided herein facilitate the analysis of gene expression in the selected subset present within a heterogeneous sample.