公开(公告)号：EP0276101A3

公开(公告)日：1989-11-23

申请号：EP88300343.6

申请日：1988-01-15

申请人： ICI AMERICAS INC.

发明人： Lewis, Joseph James ,  Perkins, Charles William ,  Trainor, Diane Amy ,  Wildonger, Richard Alan

IPC分类号： C07K5/00 ,  A61K37/64

CPC分类号： C07K5/06191 ,  A61K38/00

摘要： The invention provides a series of novel substituted peptide derivatives of the formulae la, Ib and Ic (set out hereinafter) and pharmaceutically acceptable salts thereof, in which the radicals A, R 1 , R 2 and R 4 -R 9 have the meanings defined in the following specification. The compounds of formulae la, Ib, and Ic are inhbitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula la, Ib or Ic, or a pharmaceutically acceptable salt thereof and processes and intermediates for the manufacture of compounds of formulae la, Ib, and Ic.

公开(公告)号：EP0276101A2

公开(公告)日：1988-07-27

申请号：EP88300343.6

申请日：1988-01-15

申请人： ICI AMERICAS INC.

发明人： Lewis, Joseph James ,  Perkins, Charles William ,  Trainor, Diane Amy ,  Wildonger, Richard Alan

IPC分类号： C07K5/00 ,  A61K37/64

CPC分类号： C07K5/06191 ,  A61K38/00

摘要： The invention provides a series of novel substituted peptide derivatives of the formulae la, Ib and Ic (set out hereinafter) and pharmaceutically acceptable salts thereof, in which the radicals A, R 1 , R 2 and R 4 -R 9 have the meanings defined in the following specification. The compounds of formulae la, Ib, and Ic are inhbitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula la, Ib or Ic, or a pharmaceutically acceptable salt thereof and processes and intermediates for the manufacture of compounds of formulae la, Ib, and Ic.

摘要翻译： 本发明提供了一系列新颖的式Ia，Ib和Ic的取代肽衍生物（下文阐述）及其药学上可接受的盐，其中基团A，R 1，R 2和R 2， 4> -R 9具有以下说明书中定义的含义。 式Ia，Ib和Ic的化合物是人白细胞弹性蛋白酶的抑制剂。 本发明还提供含有式Ia，Ib或Ic化合物或其药学上可接受的盐的药物组合物和用于制备式Ia，Ib和Ic化合物的方法和中间体。