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1.
公开(公告)号:EP2174665B1
公开(公告)日:2016-11-16
申请号:EP10001123.8
申请日:2004-10-22
IPC分类号: A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号: A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要: Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
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2.
公开(公告)号:EP2174665A3
公开(公告)日:2010-06-23
申请号:EP10001123.8
申请日:2004-10-22
IPC分类号: A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号: A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要: Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
摘要翻译: 提供了制备和使用基于蛋白体的免疫活性组合物的治疗制剂的方法。 包括蛋白体和脂质的免疫原性组合物可用于引发或增强非特异性先天性免疫应答,例如治疗或预防传染病。 另外,在激活先天性免疫系统后,还可以使用进一步含有抗原的免疫原性组合物来引发特异性适应性免疫应答。 此外,提供了能够改变高反应性反应或炎性免疫反应如变态反应的组合物。 这样的组合物可用作预防剂,或用于治疗或预防感染性疾病(如寄生虫,真菌,细菌或病毒感染)或改变不适当的炎性免疫反应(例如过敏反应或哮喘)的各种临床环境中。
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3.
公开(公告)号:EP2174665A2
公开(公告)日:2010-04-14
申请号:EP10001123.8
申请日:2004-10-22
IPC分类号: A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号: A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要: Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
摘要翻译: 基于一些制备和使用PROTEO的治疗式和灰的方法是提供免疫活性组合物。 所述免疫原性组合物,其包括PROTEO萨姆和脂糖,可以使用引发或增强对非特异性先天免疫应答,例如,治疗或预防感染性疾病。 此外,激活先天免疫系统后,还含有对抗原的免疫原性组合物可用于引发特异性适应性免疫应答。 进一步,提供了能够改变反应过度反应或炎性免疫应答,过敏反应的组合物:如。 搜索的组合物可被用作预防或各种临床治疗或预防感染性疾病(搜索为寄生虫,真菌,细菌或病毒感染),或年龄不适当的炎症免疫反应(:如过敏反应或哮喘。
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