公开(公告)号：EP3227276A4

公开(公告)日：2018-08-01

申请号：EP15865371

申请日：2015-11-30

申请人： IGNYTA INC

发明人： HORNBY ZACHARY DOLPH ,  LI GANG ,  ANDERSON DAVID WESLEY ,  BRODEUR GARRETT M ,  IYER RADHIKA

IPC分类号： C07D403/12 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D231/56

CPC分类号： A61K31/496 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/495 ,  A61K45/06 ,  C07D231/56 ,  C07D403/12 ,  C07D405/12 ,  A61K2300/00

摘要： Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are pharmaceutical compositions comprising a Trk inhibitor and one or more chemotherapeutic agents.