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公开(公告)号：EP3389645A1
公开(公告)日：2018-10-24
申请号：EP16876677.2
申请日：2016-12-15
申请人： Ignyta, Inc.
发明人： LI, Gang , WEI, Ge , HORNBY, Zachary D. , LIM, Jonathan Ee-Ren
IPC分类号： A61K31/00 , A61K31/416 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/166 , A61K31/18 , A61K31/365 , A61K31/416 , A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/4523 , A61K31/519 , A61K45/06 , C12Q1/68 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要： Described herein are combinations comprising a therapeutically effective amount of a first agent and a therapeutically effective amount of a second agent, wherein the first agent is an inhibitor of ALK, ROSl, TrkA, TrkB, or TrkC activity, or a combination thereof, and methods of using such combinations in the treatment of patients having cancer.
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公开(公告)号：EP3087070B1
公开(公告)日：2017-11-08
申请号：EP14824711.7
申请日：2014-12-18
申请人： Ignyta, Inc.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61P35/00
摘要： The invention is directed to pyrazolo[1,5-a]pyridine derivatives and their use as AXL and c-MET kinase inhibitors.
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公开(公告)号：EP3503887A1
公开(公告)日：2019-07-03
申请号：EP17844308.1
申请日：2017-08-22
申请人： Ignyta, Inc.
IPC分类号： A61K31/435 , A61K31/444 , A61K45/06
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公开(公告)号：EP3227276A4
公开(公告)日：2018-08-01
申请号：EP15865371
申请日：2015-11-30
申请人： IGNYTA INC
IPC分类号： C07D403/12 , A61K31/4745 , A61K31/495 , A61K31/496 , A61P35/00 , C07D231/56
CPC分类号： A61K31/496 , A61K31/4188 , A61K31/4745 , A61K31/495 , A61K45/06 , C07D231/56 , C07D403/12 , C07D405/12 , A61K2300/00
摘要： Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are pharmaceutical compositions comprising a Trk inhibitor and one or more chemotherapeutic agents.
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公开(公告)号：EP3227276A1
公开(公告)日：2017-10-11
申请号：EP15865371.7
申请日：2015-11-30
申请人： Ignyta, Inc.
发明人： HORNBY, Zachary Dolph , LI, Gang , ANDERSON, David Wesley , BRODEUR, Garrett M. , IYER, Radhika
IPC分类号： C07D403/12 , C07D231/56 , A61K31/496
CPC分类号： A61K31/496 , A61K31/4188 , A61K31/4745 , A61K31/495 , A61K45/06 , C07D231/56 , C07D403/12 , C07D405/12 , A61K2300/00
摘要： Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are pharmaceutical compositions comprising a Trk inhibitor and one or more chemotherapeutic agents.
摘要翻译： 公开了通过与另一种化学治疗剂组合施用Trk抑制剂来治疗癌症患者中的神经母细胞瘤的方法。 还公开了包含Trk抑制剂和一种或多种化学治疗剂的药物组合物。
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6.发明公开METHODS OF TREATING VARIOUS CANCERS USING AN AXL/cMET INHIBITOR ALONE OR IN COMBINATION WITH OTHER AGENTS 审中-公开方法适用于各种癌与Axl的处理/ CMET抑制剂单独或与其它物质一并
公开(公告)号：EP3027623A4
公开(公告)日：2017-03-01
申请号：EP14832882
申请日：2014-07-31
申请人： IGNYTA INC
发明人： ANGELES THELMA S , ATOR MARK A , CHENG MANGENG M , DORSEY BRUCE , HUDKINS ROBERT L , RUGGERI BRUCE A
IPC分类号： C07D491/04 , A61K31/513 , A61K31/517 , A61K35/06 , A61P35/00 , C07D401/12
CPC分类号： A61K31/513 , A61K31/517 , A61K45/06 , A61K2300/00
摘要： This application describes the use of the compound (I) or a salt thereof, either alone or in combination with other therapeutically active agents, for the treatment of particular cancers, including any solid or hematological cancer in which AXL or c-Met is over-expressed.
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公开(公告)号：EP3548007A1
公开(公告)日：2019-10-09
申请号：EP17875740.7
申请日：2017-11-29
申请人： Ignyta, Inc.
发明人： LIM, Jonathan Ee-Ren , MULTANI, Pratik S. , LANDIN, Richard , PATEL, Rupal A. , OLIVER, Jennifer Wright
IPC分类号： A61K9/20 , A61K9/48 , A61K31/517 , A61P35/00 , C07C55/08 , C07D239/88
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公开(公告)号：EP3490561A1
公开(公告)日：2019-06-05
申请号：EP17837447.6
申请日：2017-07-28
申请人： Ignyta, Inc.
IPC分类号： A61K31/4725 , A61K39/395 , A61P35/00
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公开(公告)号：EP2780338B1
公开(公告)日：2016-11-09
申请号：EP12798087.8
申请日：2012-11-14
申请人： Ignyta, Inc.
发明人： DANDU, Reddeppareddy , HUDKINS, Robert L. , JOSEF, Kurt A. , PROUTY, Catherine P. , TRIPATHY, Rabindranath
IPC分类号： C07D401/12 , C07D491/04 , A61K31/506 , A61K31/53 , A61P35/00
CPC分类号： C07D401/12 , A61K31/4725 , A61K31/506 , A61K31/513 , A61K31/517 , A61K45/06 , C07D239/54 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D491/048 , C07D491/056
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10.发明公开METHODS OF TREATING VARIOUS CANCERS USING AN AXL/cMET INHIBITOR ALONE OR IN COMBINATION WITH OTHER AGENTS 审中-公开方法适用于各种癌与Axl的处理/ CMET抑制剂单独或与其它物质一并
公开(公告)号：EP3027623A2
公开(公告)日：2016-06-08
申请号：EP14832882.6
申请日：2014-07-31
申请人： Ignyta, Inc.
发明人： ANGELES, Thelma S. , ATOR, Mark A. , CHENG, Mangeng M. , DORSEY, Bruce , HUDKINS, Robert L. , RUGGERI, Bruce A.
IPC分类号： C07D491/04 , A61P35/00 , A61K31/513 , C07D401/12
CPC分类号： A61K31/513 , A61K31/47 , A61K31/517 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： This application describes the use of the compound (I) or a salt thereof, either alone or in combination with other therapeutically active agents, for the treatment of particular cancers, including any solid or hematological cancer in which AXL or c-Met is over-expressed.
摘要翻译： 本申请描述了使用化合物（I）或其盐，单独地或与其它治疗活性剂的，用于治疗特定的癌症，包括任何固体或血液癌症中哪AXL或c-Met的过度是 表示。
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