公开(公告)号：EP3157519A4

公开(公告)日：2017-12-20

申请号：EP15810018

申请日：2015-06-18

申请人： IMMUNOLIGHT LLC ,  UNIV DUKE

发明人： TOONE ERIC J ,  GOODEN DAVID ,  BOURKE FREDERIC A ,  WALDER HAROLD

IPC分类号： C07D493/04 ,  A61K31/37 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61K31/37 ,  A61N5/0616 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/0612 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/1098 ,  C07D493/04

摘要： Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D- 10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in Fig. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an auto vaccine effect in a subject using the method.

公开(公告)号：EP3097108A4

公开(公告)日：2017-10-18

申请号：EP15740092

申请日：2015-01-23

申请人： IMMUNOLIGHT LLC ,  UNIV DUKE ,  XIA WENLE ,  GOODEN DAVID ,  SODERBLOM ERIK J ,  TOONE ERIC J ,  SPECTOR NEIL L ,  BEYER WAYNE F ,  WALDER HAROLD

发明人： XIA WENLE ,  GOODEN DAVID ,  SODERBLOM ERIK J ,  TOONE ERIC J ,  SPECTOR NEIL L ,  BEYER WAYNE F ,  WALDER HAROLD

IPC分类号： C07D493/00 ,  A61K31/37 ,  A61K31/436 ,  A61K31/4709 ,  A61K31/517 ,  A61K41/00 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/436 ,  A61K31/37 ,  A61K31/4709 ,  A61K31/517 ,  A61K41/0066 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.