专利检索 ap:("IMMUNOLIGHT LLC" OR "UNIV DUKE" OR "XIA WENLE" OR "GOODEN DAVID" OR "SODERBLOM ERIK J" OR "TOONE ERIC J" OR "SPECTOR NEIL L" OR "BEYER WAYNE F" OR "WALDER HAROLD") AND inv:"TOONE ERIC J" 第 1 页

1.

发明公开
USE OF PSORALEN DERIVATIVES AND COMBINATION THERAPY FOR TREATMENT OF CELL PROLIFERATION DISORDERS 审中-公开

公开(公告)号：EP3097108A4

公开(公告)日：2017-10-18

申请号：EP15740092

申请日：2015-01-23

申请人： IMMUNOLIGHT LLC , UNIV DUKE , XIA WENLE , GOODEN DAVID , SODERBLOM ERIK J , TOONE ERIC J , SPECTOR NEIL L , BEYER WAYNE F , WALDER HAROLD

发明人： XIA WENLE , GOODEN DAVID , SODERBLOM ERIK J , TOONE ERIC J , SPECTOR NEIL L , BEYER WAYNE F , WALDER HAROLD

IPC分类号： C07D493/00 , A61K31/37 , A61K31/436 , A61K31/4709 , A61K31/517 , A61K41/00 , A61K45/06 , A61P35/00

CPC分类号： A61K31/436 , A61K31/37 , A61K31/4709 , A61K31/517 , A61K41/0066 , A61K45/06 , A61K2300/00

摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

2.

发明公开
METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES 审中-公开

公开(公告)号：EP3157519A4

公开(公告)日：2017-12-20

申请号：EP15810018

申请日：2015-06-18

申请人： IMMUNOLIGHT LLC , UNIV DUKE

发明人： TOONE ERIC J , GOODEN DAVID , BOURKE FREDERIC A , WALDER HAROLD

IPC分类号： C07D493/04 , A61K31/37 , A61N5/06 , A61N5/10

CPC分类号： A61K31/37 , A61N5/0616 , A61N5/062 , A61N5/10 , A61N2005/0612 , A61N2005/063 , A61N2005/0659 , A61N2005/0661 , A61N2005/1098 , C07D493/04

摘要： Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D- 10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in Fig. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an auto vaccine effect in a subject using the method.

3.

发明公开
PREVENTION OF FLAP NECROSIS IN PLASTIC SURGERY 有权
标题翻译：预防HAUTLAPPENNEKROSE整形手术

公开(公告)号：EP1463440A4

公开(公告)日：2008-01-23

申请号：EP02804687

申请日：2002-12-02

申请人： UNIV DUKE

发明人： STAMLER JONATHAN S , ZENN MICHAEL R , TOONE ERIC J

IPC分类号： A61B1/00 , A61K9/06 , A61B20060101 , A61K9/00 , A61K9/08 , A61K9/20 , A61K31/04 , A61K31/095 , A61K31/167 , A61K31/724 , A61K33/00 , A61K33/04 , A61K45/06 , A61K47/40 , A61P9/00 , A61P9/10 , A61P43/00 , C07D405/14

CPC分类号： A61K31/724 , A61K31/04 , A61K31/095 , A61K31/21 , A61K33/00 , A61K45/06 , A61K2300/00

摘要： NO, NO donor or prodrug that causes formation of nitrosothiol in tissue optionally in combination with lidocaine is topically applied to pedicle of a pedicle flap or other source of blood supply to prevent necrosis in pedicle flap or in any microvascular surgery. Composition containing drug is formulated with nitrosylated polythiolated cyclodextrin to improve drug delivery.

4.

发明公开
REACTIVE OXYGEN GENERATING ENZYME INHIBITOR WITH NITRIC OXIDE BIOACTIVITY AND USES THEREOF 审中-公开
标题翻译：活性氧生成酶与有机硝酸效应及其应用抑制剂

公开(公告)号：EP1737867A4

公开(公告)日：2008-03-05

申请号：EP05736907

申请日：2005-04-20

申请人： UNIV DUKE , UNIV JOHNS HOPKINS

发明人： STAMLER JONATHAN S , TOONE ERIC J , HARE JOSHUA M

IPC分类号： C07D487/04 , A61K31/519 , C07D487/02

CPC分类号： C07D487/04 , A61K31/519

5.

发明公开
METHOD OF TREATING CARDIO PULMONARY DISEASES WITH NO GROUP COMPOUNDS 有权
标题翻译：方法的治疗心脏病肺病THROUGH链接从没有组

公开(公告)号：EP1229954A4

公开(公告)日：2005-05-25

申请号：EP00955290

申请日：2000-08-18

申请人： UNIV DUKE

发明人： STAMLER JONATHAN S , TOONE ERIC J , GOW ANDREW J

IPC分类号： G01N31/00 , A61K9/72 , A61K31/16 , A61K31/166 , A61K31/197 , A61K31/21 , A61K33/00 , A61K33/04 , A61K35/14 , A61K35/18 , A61K45/00 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P21/00 , A61P29/00 , G01N33/15 , G01N33/50 , A61M15/00 , A01K31/16 , A61M16/00 , A62B7/00 , A62B9/00 , A62B18/00

CPC分类号： C12N5/0641 , A61K31/197 , A61K31/21 , A61K33/00 , A61K33/04 , A61M2202/0275 , A61K2300/00

6.

发明公开
SUBSTITUTED HYDROXAMIC ACID COMPOUNDS 审中-公开
标题翻译： SUBSTITUIERTEHYDROXAMSÄVERVERBINDUNGEN

公开(公告)号：EP3041354A4

公开(公告)日：2017-06-14

申请号：EP14836244

申请日：2014-08-18

申请人： UNIV DUKE

发明人： ZHOU PEI , TOONE ERIC J , NICHOLAS ROBERT A

IPC分类号： A01N37/28 , A01N37/00 , A61K31/19 , C07C317/44 , C07D213/64 , C07D231/12 , C07D295/135

CPC分类号： C07C259/06 , A61K31/5375 , C07C317/44 , C07D213/64 , C07D231/12 , C07D295/135 , C07D295/155

摘要： Disclosed are compounds of formulae: (I), and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R21, R22, R23, R34, R37, R33, R39, D, Q, Y, X, X1, X3, and X4 are defined herein. These compounds are useful for treating Gram-negative bacteria infections.

摘要翻译： （I）和（II）化合物及其药学上可接受的盐，其中变量R，R 1，R 2，R 3，R 21，R 22，R 23，R 34，R 37，R 33，R 39，D，Q， Y，X，X1，X3和X4在本文中定义。这些化合物可用于治疗革兰氏阴性细菌感染。