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    Nitrogeneous compounds
    1.
    发明公开
    Nitrogeneous compounds 失效
    硝酸化合物

    公开(公告)号：EP0092945A3

    公开(公告)日：1985-01-23

    申请号：EP83302143

    申请日：1983-04-15

    申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

    发明人： Briggs, Malcolm Thomas ,  Dowell, Robert Ian ,  Thornber, Craig Willard

    IPC分类号： C07D237/34 ,  A61K31/50 ,  C07D237/22 ,  C07D237/20 ,  C07D237/24

    CPC分类号： C07D237/20 ,  C07D237/14 ,  C07D237/18 ,  C07D237/22 ,  C07D237/24 ,  C07D237/32 ,  C07D237/34

    摘要： Hydrazinopyridiazine derivatives of the formula:-
    wherein A is alkylene, wherein either R' is hydrogen and R 2 is hydrogen, alkoxycarbonyl or aralkoxycarbonyl, or R' and R 2 together form alkylidene, aralkylidene, alkoxycarbonylal- kylidene or aralkoxycarbonylalkylidene, wherein either R 3 and R 4 , which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro, trifluoromethyl, carbamoyl, cyano, alkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy, alkanoyl, aryl, aryloxy or dialkylamino, or R 3 and R 4 together with the adjacent benzene ring form indanyl, 5,6,7,8-tetrahydronaphthyl, 5-oxo-5,6,7,8-tetrahydronaphthyl, indenyl, 5,8-dihydronaphthyl or naphthyl, wherein either R 5 and R 6 , which may be the same or different, each is hydrogen or alkyl, or R 5 and R 6 together with the adjacent pyridazine ring form phthalazinyl, and wherein X is oxygen or -NHCO-, -NHCO-A'- or -NHCO-A'-0- wherein A' is alkylene, acid-addition salts thereof, processes for their manufacture and pharmaceutical composition containing them. The compounds possess antihypertensive activity.

    Nitrogeneous compounds
    2.
    发明公开
    Nitrogeneous compounds 失效
    含氮化合物。

    公开(公告)号：EP0092945A2

    公开(公告)日：1983-11-02

    申请号：EP83302143.9

    申请日：1983-04-15

    申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

    发明人： Briggs, Malcolm Thomas ,  Dowell, Robert Ian ,  Thornber, Craig Willard

    IPC分类号： C07D237/34 ,  A61K31/50 ,  C07D237/22 ,  C07D237/20 ,  C07D237/24

    CPC分类号： C07D237/20 ,  C07D237/14 ,  C07D237/18 ,  C07D237/22 ,  C07D237/24 ,  C07D237/32 ,  C07D237/34

    摘要： Hydrazinopyridiazine derivatives of the formula:-
    wherein A is alkylene, wherein either R' is hydrogen and R 2 is hydrogen, alkoxycarbonyl or aralkoxycarbonyl, or R' and R 2 together form alkylidene, aralkylidene, alkoxycarbonylal- kylidene or aralkoxycarbonylalkylidene, wherein either R 3 and R 4 , which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro, trifluoromethyl, carbamoyl, cyano, alkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy, alkanoyl, aryl, aryloxy or dialkylamino, or R 3 and R 4 together with the adjacent benzene ring form indanyl, 5,6,7,8-tetrahydronaphthyl, 5-oxo-5,6,7,8-tetrahydronaphthyl, indenyl, 5,8-dihydronaphthyl or naphthyl, wherein either R 5 and R 6 , which may be the same or different, each is hydrogen or alkyl, or R 5 and R 6 together with the adjacent pyridazine ring form phthalazinyl, and wherein X is oxygen or -NHCO-, -NHCO-A'- or -NHCO-A'-0- wherein A' is alkylene, acid-addition salts thereof, processes for their manufacture and pharmaceutical composition containing them. The compounds possess antihypertensive activity.

    Heterocyclic compounds
    3.
    发明公开
    Heterocyclic compounds 失效
    杂环衍生物。

    公开(公告)号：EP0052442A1

    公开(公告)日：1982-05-26

    申请号：EP81305020.0

    申请日：1981-10-23

    申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

    发明人： Brown, David ,  Dowell, Robert Ian ,  Hargreaves, Rodney Brian ,  Main, Brian Geoffrey

    IPC分类号： C07D285/16 ,  C07D273/04 ,  C07D253/06 ,  C07D405/04 ,  C07D417/12 ,  C07D417/04 ,  A61K31/53 ,  A61K31/535 ,  A61K31/54

    CPC分类号： C07D253/06 ,  C07C255/00 ,  C07D273/04 ,  C07D285/16 ,  C07D295/092 ,  C07D295/194 ,  Y10S514/929

    摘要： Novel heterocyclic compounds of the formula:-
    wherein either X is -CR 1 R 2 - and Y is oxygen, sulphur or -NR 3- , wherein R 1 , R 2 and R 3 , which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is oxygen, sulphur or -NH- and Y is -CH 2 -; wherein R 4 and R 5 , which may be the same or different, each is hydrogen, cyano, nitro, amino or hydroxy, or alkylthio of up to 4 carbon atoms, or has various other meanings defined in i claim 1, provided that R 4 and R 5 are not both hydrogen; or wherein R 4 and R 5 are joined together such that with the benzene ring A they form a benzheterocyclic ring as defined in claim 1; and therein the benzene ring A may optionally bear one or more further substituents; or a salt thereof where appropriate.
    These compounds possess cardiotonic properties, and some of them possess peripheral vasodilator properties, and they are useful for the treatment of acute or chronic heart failure. Representative of the compounds is N,N-dimethyl-p-(5,6-dihydro-5-oxo-4H-1,3,4-thiadiazin-2-yl)benzamide. Also disclosed are processes for the manufacture of the compounds and pharmaceutical compositions containing them.