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公开(公告)号：EP1095278B1
公开(公告)日：2005-12-07
申请号：EP99934543.2
申请日：1999-06-29
申请人： Innogenetics N.V.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2835 , G01N2800/52
摘要： The present invention relates to new methods for the specific detection, quantification and/or differential diagnosis of neurodegeneration in an individual making use of a combination assay detecting at least three neurological markers in one or more body fluids of said individual, the type and degree of neurodegeneration being reflected in the quantitative changes in the level of all of said neurological markers compared to the control sample. The present invention also relates to methods for the detection of Rab3a, SNAP25 and alpha -synuclein in cerebrospinal fluid and to the use of these methods in a combination assay for specific detection, quantification and/or differential diagnosis of neurodegeneration.
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2.发明公开MONOCLONAL ANTIBODIES SPECIFIC FOR PHF-TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION BY THESE ANTIBODIES AND THEIR APPLICATIONS 失效反对PHF-TAU，杂交瘤THESE退休，识别抗原的单克隆抗体这些抗体及其用途
公开(公告)号：EP0737208A1
公开(公告)日：1996-10-16
申请号：EP95903798.0
申请日：1994-12-14
申请人： Innogenetics N.V.
CPC分类号： C07K16/18 , C07K14/4711
摘要： The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).
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公开(公告)号：EP1112500B1
公开(公告)日：2004-09-22
申请号：EP99968716.3
申请日：1999-09-07
申请人： INNOGENETICS N.V.
发明人： HULSTAERT, Frank , VANMECHELEN, Eugeen , VANDERSTICHELE, Hugo , VAN DE VOORDE, André , VAN GOOL, Stefaan
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/6896 , G01N33/574
摘要： The present invention provides a new method for the early diagnosis of CNS damage in an individual, said CNS damage being caused by space-occupying lesions of the CNS, by invasion or metastasis of the CNS, by organisms, by anoxia or ischemia, by chemical agents, by physical agents, or by a combination of these mechanisms. This new method comprises the step of determining and/or quantifying the level of tau in said individual and comparing it to the level of tau in control healthy individuals.
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4.发明授权MONOCLONAL ANTIBODIES SPECIFIC FOR PHF-TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION BY THESE ANTIBODIES AND THEIR APPLICATIONS 失效反对PHF-TAU，杂交瘤THESE退休，识别抗原的单克隆抗体这些抗体及其用途
公开(公告)号：EP0737208B1
公开(公告)日：2006-08-02
申请号：EP95903798.7
申请日：1994-12-14
申请人： Innogenetics N.V.
IPC分类号： C07K16/18 , C07K14/47 , C12N5/20 , G01N33/577 , G01N33/68
CPC分类号： C07K16/18 , C07K14/4711
摘要： The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).
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公开(公告)号：EP1095278A2
公开(公告)日：2001-05-02
申请号：EP99934543.2
申请日：1999-06-29
申请人： INNOGENETICS N.V.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2835 , G01N2800/52
摘要： The present invention relates to new methods for the specific detection, quantification and/or differential diagnosis of neurodegeneration in an individual making use of a combination assay detecting at least three neurological markers in one or more body fluids of said individual, the type and degree of neurodegeneration being reflected in the quantitative changes in the level of all of said neurological markers compared to the control sample. The present invention also relates to methods for the detection of Rab3a, SNAP25 and α-synuclein in cerebrospinal fluid and to the use of these methods in a combination assay for specific detection, quantification and/or differential diagnosis of neurodegeneration.
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