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公开(公告)号：EP3532502A1
公开(公告)日：2019-09-04
申请号：EP17797084.5
申请日：2017-10-25
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7 , Université de Montpellier , Institut Jean Godinot , Institut Regional du Cancer de Montpellier
发明人： BENSUSSAN, Armand , ROBERT, Bruno , MARTINEAU, Pierre , CHENTOUF, Myriam , MARIE-CARDINE, Anne , GUSTINIANI, Jérôme
IPC分类号： C07K16/28
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公开(公告)号：EP3245229A1
公开(公告)日：2017-11-22
申请号：EP16700495.1
申请日：2016-01-14
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Université Paris Diderot - Paris 7 , Institut Regional du Cancer de Montpellier , Université de Montpellier
发明人： COUVINEAU, Alain , VOISIN, Thierry , NICOLE, Pascal , ROBERT, Bruno , MARTINEAU, Pierre , CHENTOUF, Myriam
CPC分类号： C07K16/286 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/73
摘要： The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
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公开(公告)号：EP3245229B1
公开(公告)日：2019-07-24
申请号：EP16700495.1
申请日：2016-01-14
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7 , Institut Regional du Cancer de Montpellier , Université de Montpellier
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公开(公告)号：EP3245228A1
公开(公告)日：2017-11-22
申请号：EP16700493.6
申请日：2016-01-14
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Université Paris Diderot - Paris 7 , Institut Regional du Cancer de Montpellier , Université de Montpellier
发明人： COUVINEAU, Alain , VOISIN, Thierry , ROBERT, Bruno , NICOLE, Pascal , CHENTOUF, Myriam , MARTINEAU, Pierre
CPC分类号： C07K16/286 , A61K39/00 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/75
摘要： The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.
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公开(公告)号：EP4034560A1
公开(公告)日：2022-08-03
申请号：EP20781351.0
申请日：2020-09-25
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Institut Regional du Cancer de Montpellier , Université de Montpellier , Sorbonne Université
发明人： PELEGRIN, André , ROBERT, Bruno , MARTINEAU, Pierre , CHAUVIN, Maëva , CHENTOUF, Myriam , DI CLEMENTE-BESSE, Nathalie
IPC分类号： C07K16/26 , A61P35/00 , A61K39/395
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公开(公告)号：EP4025604A1
公开(公告)日：2022-07-13
申请号：EP20771782.8
申请日：2020-09-03
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Montpellier , Institut Regional du Cancer de Montpellier , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Institut Pasteur de Lille , Université de Lille
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公开(公告)号：EP4382120A1
公开(公告)日：2024-06-12
申请号：EP22306787.7
申请日：2022-12-05
申请人： Institut Regional du Cancer de Montpellier , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE MONTPELLIER
发明人： LINARES, Laetitia , BOUILLIN, Alix , GAYTE, Laurie , CHENTOUF, Myriam , RISCAL, Romain , CARRERE, Sébastien , NEIVEYANS, Madeline
CPC分类号： C07K16/28 , A61K39/001102 , A61P35/04
摘要： The present disclosure relates to monoclonal antibodies directed against the external loop of SLC1A4, which monoclonal antibodies are preferably human monoclonal antibodies.
The present disclosure also relates to the therapeutic use of the said monoclonal antibodies, especially for treating serine-dependent cancers, particular SLC1A4-expressing cancers. It also relates to the in vitro and the in vivo use of the anti-SLC1A4 monoclonal antibodies disclosed therein for diagnosis purpose.
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