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1.发明公开
公开(公告)号：EP2414836A2
公开(公告)日：2012-02-08
申请号：EP10711235.1
申请日：2010-03-29
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de la Méditerranée - Aix-Marseille II
发明人： AUGER, Isabelle , ROUDIER, Jean
IPC分类号： G01N33/564 , G01N33/573 , G01N33/535
CPC分类号： G01N33/564 , C07K14/4713 , C07K14/81 , C07K14/8139 , C07K14/82 , C12N9/12 , C12N9/1205 , C12N9/78 , C12Y207/11001 , C12Y305/03015 , G01N33/6854 , G01N2800/102 , G01N2800/60
摘要： The present invention relates to peptides biomarkers that are specifically recognized by autoantibodies present in the sera of patients with Rheumatoid Arthritis (RA). More specifically, the invention provides epitopes of PAD4, of BRAF, and of calpastatin as well as methods and kits for using these sequences for the diagnosis of RA, in particular for the diagnosis of RA in CCP-negative subjects.
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公开(公告)号：EP2875356A1
公开(公告)日：2015-05-27
申请号：EP13744473.3
申请日：2013-07-23
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Université d'Aix Marseille , Assistance Publique Hôpitaux de Marseille
IPC分类号： G01N33/564 , G01N33/68
CPC分类号： G01N33/6803 , G01N33/564 , G01N33/6854 , G01N2800/101 , G01N2800/20 , G01N2800/24
摘要： The present invention relates to an in vitro method for diagnosing scleroderma in a subject, said method comprising the step of detecting in a biological sample obtained from the subject one or more autoantibodies recognizing one or more protein biomarkers selected from the group of proteins consisting of THEXl, AIFl, FGF2, EphB2, CLK1 and ANKS6.
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3.发明授权
公开(公告)号：EP2414836B1
公开(公告)日：2014-05-07
申请号：EP10711235.1
申请日：2010-03-29
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université d'Aix-Marseille
发明人： AUGER, Isabelle , ROUDIER, Jean
CPC分类号： G01N33/564 , C07K14/4713 , C07K14/81 , C07K14/8139 , C07K14/82 , C12N9/12 , C12N9/1205 , C12N9/78 , C12Y207/11001 , C12Y305/03015 , G01N33/6854 , G01N2800/102 , G01N2800/60
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