公开(公告)号：EP1429143A4

公开(公告)日：2006-04-12

申请号：EP02760625

申请日：2002-08-13

申请人： INST ANTIBODIES CO LTD

发明人： KUROSAWA YOSHIKAZU ,  AKAHORI YASUSHI ,  HIRONO YUKARI ,  KAKITA MAI ,  SUZUKI KAZUHIRO ,  OKUNO YOSHINOBU

IPC分类号： C07K16/00 ,  C07K16/10 ,  G01N33/53 ,  G01N33/536 ,  G01N33/543 ,  G01N33/50 ,  A61K39/395 ,  A61K45/00 ,  G01N33/15

CPC分类号： G01N33/54353 ,  C07K16/00 ,  C07K16/005 ,  C07K16/1018 ,  G01N33/53 ,  G01N33/5306 ,  G01N33/536

摘要： An affinitive linker is introduced into a target substance and captured by a binding partner capable of binding to the affinitive linker to thereby select a binding molecule capable of binding to the target substance. For example, a sugar chain contained in an influenza virus antigen is labeled with an affinitive linker such as biotin and allowed to bind to streptpavidin serving as a binding partner and then recovered. Thus, an antibody binding to the antigen can be easily concentrated. This method of selecting a binding molecule is useful in screening a neutralizer.