公开(公告)号：EP0448292A3

公开(公告)日：1992-01-08

申请号：EP91302191.1

申请日：1991-03-14

申请人： INSTACOOL INC. OF NORTH AMERICA

发明人： Coelho, Philip Henry ,  Wolf, Terry

IPC分类号： F25D17/02 ,  A23L3/36

CPC分类号： A23L3/36 ,  A23L3/364 ,  A61M1/0277 ,  F25D9/005 ,  F25D17/02 ,  F25D2331/809 ,  F25D2400/10 ,  F25D2400/28 ,  F25D2400/30

摘要： Rapid cooling or freezing of foodstuffs, perishables or blood products is accomplished by using a thin film membrane to totally envelope the foodstuffs or blood product only , during the heat extraction period. This thin film encapsulation system closes around the item and is held tightly to the item by atmospheric and/or hydrostatic pressure. Once the item is encapsulated, low temperature heat transfer fluids are then circulated on the exterior surface of the membrane, thus extracting the heat within the item through the thickness of the membrane. Upon completion of the necessary chilling or freezing, the atmospheric and/or hydrostatic pressure is withdrawn and the chilled or frozen item is extracted.

公开(公告)号：EP0608121A1

公开(公告)日：1994-07-27

申请号：EP94300385.5

申请日：1994-01-19

申请人： INSTACOOL INC. OF NORTH AMERICA

发明人： Coelho, Philip Henry ,  Wolf, Terry

IPC分类号： B01D9/00 ,  A61K35/16

CPC分类号： A61J1/1412 ,  A61J1/10 ,  A61J1/1462 ,  A61J1/1487 ,  A61J2205/30 ,  A61M1/0272 ,  A61M1/0277 ,  A61M1/0281 ,  A61M2202/0449 ,  B01D9/0013 ,  C07K14/75 ,  A61M2202/0071

摘要： An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.

摘要翻译： 从血液制品中颁布血纤维蛋白原的冷沉淀的手段。 仪器考虑了用于血液制品的容器，用于在容器内产生纤维蛋白原的装置，以及在装置内操作容器并随后在形成纤维蛋白原之后的方法。 该装置包括容器被支撑在其中的接收器，用于接收器的运动传递装置，以向容器施加运动，同时使容器经受温度差异导致热传递。 赋予容器的运动导致血液制品的薄涂层被布置在容器的内表面上，而这又暴露于通过容器壁的传热流体。 定位在容器内部的连续涂层，使得每个涂层被放置在改变阶段的先前涂层上。 在容器的内容物已被冷冻之后，容器的弯曲可以通过在容器内提供真空而导致冷冻材料的内爆而发生。 随后的相变回液体，然后第二次冷冻/解冻，然后离心导致冷冻馏分从其中沉淀。 血液制品容纳在其中的容器包括用于进入血液制品的开口，用于提取纤维蛋白原的出口和进入能够相对于容器的内部和外部提供压差的源。 还可以提供容器内的温度曲线的信息。

公开(公告)号：EP0448292A2

公开(公告)日：1991-09-25

申请号：EP91302191.1

申请日：1991-03-14

申请人： INSTACOOL INC. OF NORTH AMERICA

发明人： Coelho, Philip Henry ,  Wolf, Terry

IPC分类号： F25D17/02 ,  A23L3/36

CPC分类号： A23L3/36 ,  A23L3/364 ,  A61M1/0277 ,  F25D9/005 ,  F25D17/02 ,  F25D2331/809 ,  F25D2400/10 ,  F25D2400/28 ,  F25D2400/30

摘要： Rapid cooling or freezing of foodstuffs, perishables or blood products is accomplished by using a thin film membrane to totally envelope the foodstuffs or blood product only , during the heat extraction period. This thin film encapsulation system closes around the item and is held tightly to the item by atmospheric and/or hydrostatic pressure. Once the item is encapsulated, low temperature heat transfer fluids are then circulated on the exterior surface of the membrane, thus extracting the heat within the item through the thickness of the membrane. Upon completion of the necessary chilling or freezing, the atmospheric and/or hydrostatic pressure is withdrawn and the chilled or frozen item is extracted.

摘要翻译： 食品，易腐食品或血液制品的快速冷却或冷冻是通过在热提取期间使用薄膜来完全包封食品或血液制品而完成的。 该薄膜封装系统在物品周围关闭，并通过大气和/或静水压力紧紧地保持在物品上。 一旦物品被封装，低温传热流体然后在膜的外表面上循环，从而通过膜的厚度提取物品内的热量。 完成必要的冷却或冷冻后，取出大气和/或静水压力，并抽出冷冻或冷冻物品。