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    NON-NEWTONIAN FLUID SPRAY APPLICATOR AND METHOD
    2.
    发明公开
    NON-NEWTONIAN FLUID SPRAY APPLICATOR AND METHOD 审中-公开
    方法和装置喷涂非牛顿流体

    公开(公告)号：EP1409144A2

    公开(公告)日：2004-04-21

    申请号：EP01935118.8

    申请日：2001-05-07

    申请人： BAXTER INTERNATIONAL INC.

    发明人： LEVINSON, Mitchell, E. ,  EPSTEIN, Gordon, H.

    IPC分类号： B05B7/08

    CPC分类号： A61M11/02 ,  A61M35/003 ,  A61M2202/0449 ,  B05B1/267 ,  B05B7/066

    摘要： The present invention discloses a spray applicator and method of spraying liquids to an area of interest. More particularly, the present invention is particularly useful in spraying non-Newtonian fluids, such as polymer solutions, especially aqueous fibrinogen agents, to a work surface. The spray applicator of the present invention comprises a liquid-dispensing aperture (14), a spray plate (16) capable of receiving the liquid dispensed from the liquid-dispensing aperture (14), and a gas nozzle (18) to provide a stream of carrier gas. The liquid is dispensed onto the spray plate in a plurality of forms, including, for example, a steam or as droplets. The stream of carrier gas flows proximate a shear edge formed on the spray plate. The kinetic energy of the flowing stream of carrier gas draws the liquid off the shear edge of the spray plate resulting in the atomizing of the liquid.

    PROCESS OF PREPARATION OF AN AUTOLOGOUS FIBRIN GLUE
    3.
    发明授权
    PROCESS OF PREPARATION OF AN AUTOLOGOUS FIBRIN GLUE 失效
    VERFAHREN ZUR HERSTELLUNG EINES AUTOLOGEN FIBRINKLEBERS

    公开(公告)号：EP0877632B1

    公开(公告)日：2003-03-19

    申请号：EP97942946.1

    申请日：1997-09-13

    申请人： Tarantino, Flavio ,  Benincasa, Carlo ,  CLAROL A.G.

    发明人： Tarantino, Flavio ,  Benincasa, Carlo ,  IANNINI, ROCCO ,  Rao, Walter

    IPC分类号： A61L24/10 ,  A61M1/02 ,  C07K14/75

    CPC分类号： C07K14/75 ,  A61L24/106 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/3693 ,  A61M2202/0449

    摘要： A process of preparation of autologous fibrin glue for surgical use is disclosed, comprising the steps of taking a sample of blood of the same patient and of concentrating progressively by centrifugation the sample for obtaining a basic product, which when mixed with a starter and other suitable additives produces the fibrin glue ready to be used. A preferred embodiment of the process consists of a closed system using three different plastic bags connected to one another by sealed tubes. More particularly in the first bag the blood sample taken from the patient is collected and mixed with an anticoagulating agent, then separating the plasma from the erythrocytes by centrifugation, said plasma is transferred into the second bag provided with a membrane, where through another centrifugation fibrinogen enriched plasma is separated and transferred to one of the two separated parts forming the third bag, while the other part of the bag contains a thrombin solution, so that by extracting contemporaneously the contents of said two parts and letting them flowing together to a terminal needle, the fibrin glue ready to be used is directly obtained, carrying out a closed system avoiding any contamination of the products.

    摘要翻译： 公开了一种制备用于外科用途的自体纤维蛋白胶的方法，包括以下步骤：取同一患者的血液样品，并逐渐浓缩样品以获得碱性产物，当与起始剂和其它合适的 添加剂生产出可以使用的纤维蛋白胶。 该方法的优选实施方案包括使用三个不同的塑料袋的封闭系统，该塑料袋通过密封管彼此连接。 更特别地，在第一袋中，收集从患者取出的血液样品与抗凝剂混合，然后通过离心将血浆与红细胞分离，将所述血浆转移到设有膜的第二个袋中，通过另一个离心纤维蛋白原 将富集的血浆分离并转移到形成第三袋的两个分离部分中的一个，而袋的另一部分含有凝血酶溶液，使得通过同时提取所述两个部分的内容物并使它们一起流到末端针 直接获得使用的纤维蛋白胶，进行封闭的系统，避免产品受到污染。

    POWDER DELIVERY DEVICE
    5.
    发明公开
    POWDER DELIVERY DEVICE 有权
    粉末分配器

    公开(公告)号：EP2373373A2

    公开(公告)日：2011-10-12

    申请号：EP09796044.7

    申请日：2009-12-15

    申请人： ProFibrix BV

    发明人： GREENHALGH, Paul ,  GRIMBERGEN, Joseph Maria ,  HARVEY, Oliver

    IPC分类号： A61M35/00 ,  A61M13/00

    CPC分类号： A61M35/00 ,  A61M11/00 ,  A61M11/008 ,  A61M15/0008 ,  A61M35/003 ,  A61M2202/0425 ,  A61M2202/0449 ,  A61M2205/8225

    摘要： A device (20) for the topical dispensing of a powder, typically a powder medicament, comprises, or is adapted to be coupled to, a powder receptacle (31) and a gasflow generator. The gasflow generator is adapted, in use, to cause gas 5 to flow through the device (20), which further comprises an agitator by which the powder and/or the powder receptacle (31) can be mechanically agitated. Actuation of the gasflow generator, which causes gas to flow through the device (20) and to entrain powder from the powder receptacle (31), thereby to dispense powder from the device (20), is accompanied by actuation of the agitator, 10 causing the powder receptacle (31) to be mechanically agitated, thereby facilitating the release of powder from the powder receptacle (31).

    LOW DENSITY LIPOPROTEIN/FIBRINOGEN ADSORBENT AND ADSORPTION APPARATUS CAPABLE OF WHOLE BLOOD TREATMENT
    6.
    发明公开
    LOW DENSITY LIPOPROTEIN/FIBRINOGEN ADSORBENT AND ADSORPTION APPARATUS CAPABLE OF WHOLE BLOOD TREATMENT 有权
    LIPOPROTEIN NIEDERER DICHTE / FIBRINOGEN ADSORBENS UNDGERÄTFÜRDIE VOLLBLUTBEHANDLUNG

    公开(公告)号：EP1621220A1

    公开(公告)日：2006-02-01

    申请号：EP04729289.1

    申请日：2004-04-23

    申请人： KANEKA CORPORATION

    发明人： NAKATANI, Masaru ,  KOBAYASHI, Akira ,  NISHIMOTO, Takehiro ,  FURUYOSHI, Shigeo

    IPC分类号： A61M1/36

    CPC分类号： A61M1/3633 ,  A61M2202/0449 ,  A61M2202/046 ,  A61M2202/0057

    摘要： The present invention provides an adsorbent, an adsorption method, and an adsorber for efficiently adsorbing low-density lipoproteins and fibrinogen directly from a body fluid, particularly whole blood, to decrease the concentrations of these components in the body fluid with minimizing losses of useful substances such as HDL and albumin. The adsorbent includes a tryptophan derivative and a polyanionic compound which are immobilized on a water-insoluble porous carrier, wherein the amount of the immobilized polyanionic compound is 0.10 µmol to 1.5 µmol per milliliter of wet volume of the adsorbent, and the molar ratio of the amount of the immobilized tryptophan derivative to the amount of the immobilized polyanionic compound is 1 to 70. The adsorbent is capable of whole blood treatment for safely and efficiently adsorbing low-density lipoproteins and fibrinogen.

    摘要翻译： 本发明提供一种吸附剂，吸附方法和吸附剂，用于从体液，特别是全血直接有效吸附低密度脂蛋白和纤维蛋白原，以最小化有用物质的损失来降低体液中这些成分的浓度 如HDL和白蛋白。 吸附剂包括固定在水不溶性多孔载体上的色氨酸衍生物和聚阴离子化合物，其中固定化聚阴离子化合物的量为每毫升湿体积的吸附剂为0.10μmol至1.5μmol，并且 固定化色氨酸衍生物的量相对于固定化聚阴离子化合物的量为1〜70。吸附剂能够进行全血处理以安全有效地吸附低密度脂蛋白和纤维蛋白原。

    COMPONENT MIXING CATHETER
    7.
    发明授权
    COMPONENT MIXING CATHETER 有权
    导管成分混合允许

    公开(公告)号：EP1117460B1

    公开(公告)日：2005-01-12

    申请号：EP99950119.0

    申请日：1999-10-01

    申请人： BAXTER INTERNATIONAL INC.

    发明人： EPSTEIN, Gordon, Howard ,  LEVINSON, Mitchell, E.

    IPC分类号： A61M37/00

    CPC分类号： A61M37/00 ,  A61M2202/0425 ,  A61M2202/0449

    摘要： A dual catheter (360) for delivery of a two component sealant (22) such as a fibrinogen, has coaxial inner and outer catheters (372, 364) respectively, each of which conveys a sealant component (fibrinogen or thrombin). The dual catheter (360) has a mixing volume at its distal end to mix the sealant immediately prior to delivery. The inner catheter (366) is reciprocally movable to clear clogs from the mixing volume. Optional features include a channeled plug-like tip (366) to the inner catheter, and a malleable or resilient material at the distal tip (362) to resist tissue damage.

    METHOD AND DEVICE FOR SEPARATING FIBRIN MONOMER FROM BLOOD PLASMA
    8.
    发明公开
    METHOD AND DEVICE FOR SEPARATING FIBRIN MONOMER FROM BLOOD PLASMA 失效
    方法和装置用于分离纤维蛋白用等离子体

    公开(公告)号：EP0794824A4

    公开(公告)日：1998-10-21

    申请号：EP95942533

    申请日：1995-12-01

    申请人： SQUIBB & SONS INC

    发明人： HOLM NIELS ERIK ,  EDWARDSON PETER ANDREW DAVID

    IPC分类号： A61K38/16 ,  A61M1/02 ,  A61M1/36 ,  B01D21/01 ,  B01D21/08 ,  B01D21/20 ,  B04B3/00 ,  B04B5/04 ,  C07K1/14 ,  C07K14/78 ,  G01N33/49 ,  B01D21/26

    CPC分类号： G01N33/491 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0449 ,  A61M2202/045 ,  B01D21/01 ,  B01D21/08 ,  B01D21/20 ,  B01D21/2405 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0442 ,  B04B2005/0485 ,  Y10T436/111666 ,  Y10T436/25375

    摘要： A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added. The separation of fibrin monomer from the plasma fraction in the second chamber is carried out during continued centrifugation whereby a fibrin polymer is deposited on the cylindrical outer wall of said second chamber, whereafter the fluid fraction collected at the bottom of the second chamber is transferred while influenced by the piston body to the first chamber. The fraction with fibrin polymer remaining in the second chamber is substantially deposited on the cylindrical wall and is caused to be dissolved by addition of a solvent and by centrifugation, whereafter it is transferred to a receiving container by passing after addition of a binder to the enzyme through a filter removing said enzyme, whereby a fibrin monomer containing solution is provided.

    APPLICATOR
    9.
    发明公开
    APPLICATOR 审中-公开

    公开(公告)号：EP3225172A1

    公开(公告)日：2017-10-04

    申请号：EP17161732.7

    申请日：2017-03-20

    申请人： Terumo Kabushiki Kaisha

    发明人： Kai, Miho ,  Fukui, Kunio ,  Isihara, Hiroyuki ,  Souma, Yuuki ,  Chino, Naotaka

    IPC分类号： A61B17/00 ,  A61M5/19 ,  A61M5/315 ,  B05B7/04 ,  B01F13/00 ,  A61L24/10 ,  A61M5/31

    CPC分类号： A61M5/2066 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00522 ,  A61M5/19 ,  A61M5/2053 ,  A61M5/2448 ,  A61M5/31 ,  A61M5/31511 ,  A61M5/31596 ,  A61M35/003 ,  A61M2005/3128 ,  A61M2202/0425 ,  A61M2202/0449 ,  B05B7/0408 ,  B05B7/0483 ,  B05B7/2464 ,  B05B7/2472

    摘要： There is provided an applicator including: a first liquid flow path through which a first liquid containing fibrinogen passes; a second liquid flow path through which a second liquid containing thrombin passes; a confluence section in which the first liquid and the second liquid merge with each other to form a mixed liquid; and a gas flow path through which a gas for jetting the mixed liquid passes. At least part of a wall portion defining the confluence section is composed of a gas-permeable membrane that is impermeable to the mixed liquid and permeable to the gas. The length of the gas-permeable membrane in a direction in which the mixed liquid flows through the confluence section is 5.0 to 39.0 mm. The flow rate of the gas permeating through the gas-permeable membrane is 0.3 to 2.4 L/minute.

    摘要翻译： 提供一种涂抹器，其包括：第一液体流动路径，含有纤维蛋白原的第一液体通过该第一液体流动路径; 第二液体流动路径，含有凝血酶的第二液体通过该第二液体流动路径; 合流部分，其中第一液体和第二液体彼此合并以形成混合液; 以及用于喷射混合液体的气体通过的气体流路。 限定合流部分的壁部分的至少一部分由透气膜构成，该透气膜对混合液体是不可渗透的并且可渗透气体。 透气膜在混合液流过合流部的方向上的长度为5.0〜39.0mm。 透过气体透过膜的气体的流量为0.3〜2.4L /分钟。