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1.发明授权
公开(公告)号：EP0197062B1
公开(公告)日：1991-01-09
申请号：EP85904647.6
申请日：1985-09-26
申请人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE PARIS VI , UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
发明人： MONJOUR, Louis , ROSETO, Alberto , BERNEMAN, Armand , GUILLEMIN-DEBONS, Marie-Claude , DOMURADO, Martine , PERIES, Serge
IPC分类号： C12P21/00 , A61K39/008 , G01N33/577
摘要： The invention relates to hybridomas producing anti-Leishmania monoclonal antibodies which are characterized by their capacity to inhibit the infection of sarcomateous cells by the promastigote forms of one or a plurality of Leishmania species when those sarcomateous cells are contacted with said promastigote forms pre-incubated with the monoclonal antibodies under conditions which, in the absence of said monoclonal antibodies, would result in a high parasitemy in said cells. These monoclonal antibodies and the proteins of parasites which they recognize may be used in operations for detecting leishmanioses.
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2.发明公开ANTICORPS MONOCLONAUX ANTI-LEISHMANIA, HYBRIDOMES SECRETEURS DE CES ANTICORPS, ANTIGENES DE LEISHMANIA RECONNUS PAR CES ANTICORPS, PROCEDE D'OBTENTION ET APPLICATIONS DE CES ANTICORPS MONOCLONAUX ET DE CES ANTIGENES 失效ANTILEISHMANIA单克隆抗体，该抗体杂交瘤细胞退休所检测到LEISHMANIAANTIGENE，方法的生产和使用这种单克隆抗体和抗原的这些抗体。
公开(公告)号：EP0197062A1
公开(公告)日：1986-10-15
申请号：EP85904647.0
申请日：1985-09-26
申请人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE PARIS VI , UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE
发明人： MONJOUR, Louis , ROSETO, Alberto , BERNEMAN, Armand , GUILLEMIN-DEBONS, Marie-Claude , DOMURADO, Martine , PERIES, Serge
摘要： Hybridomes produisant des anticorps monoclonaux anti-Leishmania qui sont caractérisés par leur capacité à inhiber l'infection de cellules sarcomateuses par les formes promastigotes d'une ou plusieurs espèces de Leishmania, lorsque ces cellules sarcomateuses sont mises en contact avec lesdites formes promastigotes pré-incubées avec ces anticorps monoclonaux dans des conditions qui, en l'absence desdits anticorps monoclonaux, conduiraient à une parasitémie élevée dans lesdites cellules. Ces anticorps monoclonaux et les protéines de parasites qu'ils reconnaissent peuvent être mis en oeuvre dans des opérations de détections des leishmanioses.
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公开(公告)号：EP2451450A1
公开(公告)日：2012-05-16
申请号：EP10740336.2
申请日：2010-07-06
申请人： Institut Pasteur
IPC分类号： A61K31/19 , A61K31/197 , A61K31/201 , A61P33/02
CPC分类号： C07D241/12 , A61K31/19 , A61K31/197 , A61K31/201 , Y02A50/414
摘要： The present invention relates to a new class of compounds of the general Formula (i): wherein R 1 is selected from the group consisting of: a substituted or unsubstituted C 1 -C 10 alkyl group and a polar atom selected from the group consisting of: oxygen, nitrogen, sulfur or halogen atom; R 2 and R 3 are polar groups chosen from the group consisting of: =O, =NH, -NH 2 , -OH, =S, -X 1 wherein X 1 is a halogen atom; and isomers thereof, which can in particular be used as inhibitors of Proline Racemase, as a medicament and as a component of a pharmaceutical composition. Also disclosed are in silico methods to determine inhibitors of a target using a novel structural progression approach.
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4.发明授权CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF 有权晶体结构克氏锥虫脯氨酸消旋酶（TcPRACA）及其使用
公开(公告)号：EP1629092B1
公开(公告)日：2010-12-01
申请号：EP04743784.3
申请日：2004-06-01
发明人： MINOPRIO, Paola , ALZARI, Pedro , BUSCHIAZZO, Alejandro , DEGRAVE, Wim , GREGOIRE, Christophe, Inst. Gulbenkian de Ciencia , CHAMOND, Nathalie , BERNEMAN, Armand
IPC分类号： C07K14/44
CPC分类号： C12N9/90 , C07K2299/00 , C30B7/00 , C30B29/58 , Y02A90/26
摘要： The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
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5.发明授权Inhibitors of proline racemase enzymes for the treatment of Trypanosoma spp infections 有权对锥虫属感染的治疗脯氨酸消旋酶抑制剂
公开(公告)号：EP2451450B1
公开(公告)日：2014-07-02
申请号：EP10740336.2
申请日：2010-07-06
申请人： Institut Pasteur
IPC分类号： A61K31/19 , A61K31/197 , A61K31/201 , A61P33/02
CPC分类号： C07D241/12 , A61K31/19 , A61K31/197 , A61K31/201 , Y02A50/414
摘要： The present invention relates to a new class of compounds of the general Formula (i): wherein R 1 is selected from the group consisting of: a substituted or unsubstituted C 1 -C 10 alkyl group and a polar atom selected from the group consisting of: oxygen, nitrogen, sulfur or halogen atom; R 2 and R 3 are polar groups chosen from the group consisting of: =O, =NH, -NH 2 , -OH, =S, -X 1 wherein X 1 is a halogen atom; and isomers thereof, which can in particular be used as inhibitors of Proline Racemase, as a medicament and as a component of a pharmaceutical composition. Also disclosed are in silico methods to determine inhibitors of a target using a novel structural progression approach.
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6.发明公开CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF 有权晶体结构克氏锥虫脯氨酸消旋酶（TcPRACA）及其使用
公开(公告)号：EP1629092A2
公开(公告)日：2006-03-01
申请号：EP04743784.3
申请日：2004-06-01
发明人： MINOPRIO, Paola , ALZARI, Pedro , BUSCHIAZZO, Alejandro , DEGRAVE, Wim , GREGOIRE, Christophe, Inst. Gulbenkian de Cienca , CHAMOND, Nathalie , BERNEMAN, Armand
IPC分类号： C12N9/00
CPC分类号： C12N9/90 , C07K2299/00 , C30B7/00 , C30B29/58 , Y02A90/26
摘要： The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
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7.发明公开IDENTIFICATION AND CHARACTERIZATION OF RACEMASES, DEFINITION OF PROTEIN SIGNATURES, AND A TEST FOR DETECTING D-AMINO ACID AND FOR SCREENING MOLECULES CAPABLE OF INHIBITING THE ACTIVITY OF RACEMASE, ESPECIALLY PROLINE RACEMASE 审中-公开识别和种族Masen，蛋白质特征和测试用于D-氨基酸的鉴定和进行筛选分子的定义的表征那场比赛Masen，尤其是脯氨酸RACE Masen抑制酶活性的影响
公开(公告)号：EP1592788A2
公开(公告)日：2005-11-09
申请号：EP04710107.6
申请日：2004-02-11
CPC分类号： G01N33/573 , C12N9/90 , C12Q1/26 , C12Q1/533 , G01N33/6806 , G01N2333/99 , G01N2500/02 , Y02A90/26
摘要： This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.
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