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13 条记录 (耗时 0.015 秒)

    Methods, compositions and uses thereof for reduction of stress
    1.
    发明公开
    Methods, compositions and uses thereof for reduction of stress 失效
    Verfahren，Zusammensetzungen und ihre Anwendungen gegen Stress。

    公开(公告)号：EP0183436A2

    公开(公告)日：1986-06-04

    申请号：EP85308266.7

    申请日：1985-11-13

    申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC. ,  YALE UNIVERSITY

    发明人： Warren, Craig B. ,  Leight, Ronald S. ,  Withycombe, Donald Arthur ,  Mookherjee, Braja Dulal ,  Trenkle, Robert Walter ,  Munteanu, Marina Alice ,  Benaim, Carlos ,  Walter, Henry G. Jr. ,  Schwartz, Gary E.

    IPC分类号： A61K35/78 ,  A61K7/26

    CPC分类号： A61K36/185 ,  A61K36/752 ,  A61K36/84 ,  A61K2300/00

    摘要： Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an effective amount of a physiological and/or subjective stress reactivity-reducing substance selected from the group consisting of:

    (i) Nutmeg Oil;
    (ii) Mace Extract;
    (iii) Neroli Oil;
    (iv) Valerian Oil;
    (v) Myristicin;
    (vi) Isoelemicin; and
    (vii) Elemicin.

    Administration is through inhalation or transdermally using one or more of the above ingredients alone or in a suitable composition such as ethanol and/or a perfume composition, cologne or perfumed article (e.g., air freshener or deodorant stick). Also described is a method for detecting the reduction of physiological and/or subjective reactivity to stress in a human.

    摘要翻译： 描述了一种用于在经受应激条件的人中降低生理和/或主观反应性的方法。 该方法包括向这些人施用有效量的选自以下的生理和/或主观应激反应性降低物质：（i）肉豆蔻油; （ii）麦芽提取物; （iii）Neroli油; （iv）缬草油; （v）肉豆蔻酸; （vi）等离子素; 和（vii）Elemicin。 通过吸入或透皮地使用一种或多种上述成分单独或在合适的组合物如乙醇和/或香料组合物，古龙水或香水制品（例如空气清新剂或除臭剂棒）中。 还描述了一种用于检测人的生理和/或主观反应性的压力的方法。

    1,2,3,3,5,6,-Hexamethyl-bicyclo(2.2.2)-oct-5-en-2-ol, process for producing same, intermediates useful in said process and organoleptic uses of same
    5.
    发明公开
    1,2,3,3,5,6,-Hexamethyl-bicyclo(2.2.2)-oct-5-en-2-ol, process for producing same, intermediates useful in said process and organoleptic uses of same 失效
    1,2,3,3,5,6，-HEXAMETHYL-BICYCLO（2.2.2）-OCT-5-EN-2-OL，其生产方法，在该方法中有用的中间体及其有机合成用途

    公开(公告)号：EP0148301A3

    公开(公告)日：1986-04-09

    申请号：EP84100199

    申请日：1984-01-10

    申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.

    发明人： Evers, William John ,  Mookherjee, Braja Dulal ,  Van Ouwerkerk, Anton ,  Van Loveren, Augustinus Gysbertus

    IPC分类号： C07C69/145 ,  C07C67/293 ,  C07C35/50 ,  C07C29/40 ,  C07C45/65 ,  C07C45/62 ,  A61K07/46

    CPC分类号： C11B9/0049 ,  C07C35/31 ,  C07C45/62 ,  C07C45/69 ,  C07C49/633

    摘要： Described is 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol as a mixture of isomers and in its isomeric forms having the structures:
    and the uses thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles, and colognes. Also described is a novel process for preparing 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol by first reacting the compound having the structure:
    with the compound having the structure:
    in order to produce the ketone defined according to the structure:
    which is hydrogenated to form the compound having the structure:
    and further hydrogenated to form the ketone having the structure:
    This ketone is reacted with CH 3 M wherein M represents Li or MgX and wherein X is chloro. bromo or iodo to form the organometallic intermediate defined according to the structures:
    These compounds are then hydrolyzed with dilute acid to form the organoleptically useful 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol isomers of our invention defined according to the structures:

    摘要翻译： 描述为1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇作为异构体的混合物，其异构体具有以下结构：和 其用于增强或增强香料组合物，香料制品和古龙水的香气。 还描述了一种制备1,2,3,3,5,6-六甲基 - 双环[2.2.2]辛-5-烯-2-醇的新方法，首先使具有以下结构的化合物：与 具有以下结构的化合物：，以制备根据以下结构定义的酮：，其被氢化以形成具有以下结构的化合物：＆lt; CHEM＆gt;并进一步氢化以形成具有以下结构的酮： CHEM>该酮与CH 3 M反应，其中M表示Li或MgX，其中X是氯，溴或碘，以形成根据以下结构定义的有机金属中间体：然后用稀酸水解这些化合物以形成感官有用的 本发明的1,2,3,3,5,6-六甲基双环[2.2.2]辛-5-烯-2-醇异构体根据以下结构定义：

    1,2,3,3,5,6,-Hexamethyl-bicyclo(2.2.2)-oct-5-en-2-ol, process for producing same, intermediates useful in said process and organoleptic uses of same
    6.
    发明公开
    1,2,3,3,5,6,-Hexamethyl-bicyclo(2.2.2)-oct-5-en-2-ol, process for producing same, intermediates useful in said process and organoleptic uses of same 失效
    1,2,3,3,5,6六甲基双环（2,2,2）辛-5-烯-2-醇及其制造方法，在该方法中互连和其感官应用是有用的。

    公开(公告)号：EP0148301A2

    公开(公告)日：1985-07-17

    申请号：EP84100199.3

    申请日：1984-01-10

    申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.

    发明人： Evers, William John ,  Mookherjee, Braja Dulal ,  Van Ouwerkerk, Anton ,  Van Loveren, Augustinus Gysbertus

    IPC分类号： C07C69/145 ,  C07C67/293 ,  C07C35/50 ,  C07C29/40 ,  C07C45/65 ,  C07C45/62 ,  A61K7/46

    CPC分类号： C11B9/0049 ,  C07C35/31 ,  C07C45/62 ,  C07C45/69 ,  C07C49/633

    摘要： Described is 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol as a mixture of isomers and in its isomeric forms having the structures:
    and the uses thereof in augmenting or enhancing the aroma of perfume compositions, perfumed articles, and colognes.
    Also described is a novel process for preparing 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol by first reacting the compound having the structure:
    with the compound having the structure:
    in order to produce the ketone defined according to the structure:

    which is hydrogenated to form the compound having the structure:
    and further hydrogenated to form the ketone having the structure:
    This ketone is reacted with CH 3 M wherein M represents Li or MgX and wherein X is chloro. bromo or iodo to form the organometallic intermediate defined according to the structures:
    These compounds are then hydrolyzed with dilute acid to form the organoleptically useful 1,2,3,3,5,6-hexamethyl-bicyclo[2.2.2]oct-5-en-2-ol isomers of our invention defined according to the structures:

    摘要翻译： 描述是1,2,3,3,5,6六甲基[2.2.2]辛-5-烯-2-醇在具有以下结构的其异构体和异构体形式的混合物：和 在增加或增强香料组合物，已加香制品，古龙水和香气用途。 如此描述是的新方法通过首先使该化合物具有以下结构的制备1,2,3,3,5,6六甲基[2.2.2]辛-5-烯-2-醇使用 具有该结构的化合物：为了产生雅丁定义为结构的酮：其中被氢化，以形成具有该结构的化合物所有和进一步加氢，以形成具有该结构的酮：< CHEM>这酮进行反应与CH3M worin中号darstellt Li或MGX和worin X是氯，溴或碘，以形成雅丁定义为结构的有机金属中间体：这些化合物，然后用稀酸水解，以形成感官有用 1,2,3,3,5,6-hexamethylbicyclo [2.2.2]我们的发明限定gemäß到所述结构的辛-5-烯-2-醇的异构体：>

    Macrocyclic musk composition, organoleptic uses thereof and process for preparing same
    10.
    发明公开
    Macrocyclic musk composition, organoleptic uses thereof and process for preparing same 审中-公开
    大环麝香组合物，其感官用途，以及用于制备它们的方法

    公开(公告)号：EP1308497A3

    公开(公告)日：2004-01-28

    申请号：EP02257554.2

    申请日：2002-10-31

    申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.

    发明人： Mookherjee, Braja Dulal ,  Narula, Anubhav P. S. ,  Monteleone, Michael G. ,  Trenkle, Robert W.

    IPC分类号： C11B9/00

    CPC分类号： C11B9/0038

    摘要： Described are mixtures consisting essentially of oxomacrocyclic compounds containing greater than about 40 weight % Δ 3 -cyclotetradecen-1-one and greater than about 40 weight % cyclotetradecanone and less than about 5 weight %, of Δ 2 -cyclo-tetradecen-1-one, perfumery uses thereof and chemo-selective catalytic hydrogen process for preparing same by hydrogenating mixtures containing significant concentrations, greater than 15 weight %, of Δ 2 -cyclotetradecen-1-one. The oxocarbocyclic compound-containing mixtures have advantageous musk aroma imparting, augmenting and enhancing perfumery properties causing the mixtures to be useful in perfume compositions, perfumed articles and perfumed polymers, including particles and fibers produced therefrom.