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公开(公告)号：EP3226862A4
公开(公告)日：2018-05-09
申请号：EP15866060
申请日：2015-12-07
发明人： LI PENG , ZHENG HAILIN , SNYDER GRETCHEN , WENNOGLE LAWRENCE P , HENDRICK JOSEPH
IPC分类号： A61K31/4375 , A61P25/00 , C07D471/14
CPC分类号： A61K31/4162 , A61K2300/00 , C07D209/58 , C07D403/14 , C07D471/14
摘要： The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.
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公开(公告)号：EP3010509A4
公开(公告)日：2016-11-23
申请号：EP14812994
申请日：2014-06-20
发明人： ABE TAKASHI , BUCKTON GRAHAM , DAVIS ROBERT , HOOPER MARK , LI PENG , MARUYAMA HIDEAKI , TAKASUGA MASAHIRO , WENNOGLE LAWRENCE P , YAMAMOTO YUHEI , YAMASHITA HIRONORI
IPC分类号： C07D487/14 , A61K31/519 , A61K31/57
CPC分类号： C07D487/14
摘要： The present invention relates to crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, and methods of making and using such crystals.
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公开(公告)号：EP2956141A4
公开(公告)日：2016-10-26
申请号：EP14752171
申请日：2014-02-17
发明人： WENNOGLE LAWRENCE P , DAVIS ROBERT
IPC分类号： A61K31/519 , A61K45/06 , A61P9/00 , C07D487/04 , C07D487/14
CPC分类号： A61K31/519 , A61K45/06
摘要： The invention relates to the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment of diseases or disorders characterized by disruption of or damage to various cGMP/PKG mediated pathways. In one embodiment the invention relates to inhibitors of phosphodiesterase 1 (PDE1) for treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke.
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公开(公告)号：EP2717877A4
公开(公告)日：2014-11-12
申请号：EP12796910
申请日：2012-06-11
发明人： LI PENG , ZHENG HAILIN , ZHAO JUN , WENNOGLE LAWRENCE P
IPC分类号： A61K31/505 , A61K31/519 , A61P25/00 , A61P27/06 , C07D487/04 , C07D487/14
CPC分类号： A61K31/519 , A61K8/69 , A61K9/0048 , A61K31/165 , A61K31/19 , A61K31/565 , A61K31/57 , A61K45/06 , A61Q7/00 , C07D487/12 , C07D487/14 , A61K2300/00
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公开(公告)号：EP2320731A4
公开(公告)日：2012-09-26
申请号：EP09755263
申请日：2009-05-27
CPC分类号： A61K31/4985 , A61K9/0053 , A61K31/198 , A61K31/44 , A61K31/5383 , A61K45/06 , C07D471/14 , C07D498/14
摘要： Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT 2A , SERT and/or dopamine D 2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.
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公开(公告)号：EP3091982A4
公开(公告)日：2017-10-18
申请号：EP15735265
申请日：2015-01-09
发明人： ZHANG QIANG , PENG YOUYI , LI PENG , BEARD J DAVID , WENNOGLE LAWRENCE P , TOMESCH JOHN
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04 , C07B59/002 , C07B2200/05 , C07D235/30 , C07D277/82 , C07D401/12
摘要： The invention provides novel compounds, composition comprising said compounds and methods for inhibiting CK1 as well as methods of treating CK1 related disorders such as Alzheimer's disease comprising administering a therapeutically effective amount of a CK1 inhibitor to a patient in need thereof.
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7.发明公开
公开(公告)号：EP3091983A4
公开(公告)日：2017-07-05
申请号：EP15735408
申请日：2015-01-08
IPC分类号： A61K31/519 , A61K31/53 , A61K45/06 , A61P25/16 , C07D487/04
CPC分类号： A61K31/519 , A61K9/0048 , A61K31/53 , A61K45/06 , C07D487/04 , C07D487/14 , A61K2300/00
摘要： The present invention relates to a product comprising a PDE1 inhibitor and a PDE2 inhibitor, in free or salt form, pharmaceutical compositions comprising them and their use as pharmaceuticals for the treatment of cAMP and/or cGMP related disorders.
摘要翻译： 本发明涉及包含游离或盐形式的PDE1抑制剂和PDE2抑制剂的产品，包含它们的药物组合物以及它们作为用于治疗cAMP和/或cGMP相关病症的药物的用途。
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公开(公告)号：EP2161998A4
公开(公告)日：2011-01-05
申请号：EP08768098
申请日：2008-06-04
发明人： WENNOGLE LAWRENCE P , LI PENG , ZHAO JUN
IPC分类号： C07D213/65 , A61K31/44 , A61P25/00 , C07D213/69 , C07D213/74
CPC分类号： C07D213/65 , C07D213/69 , C07D213/74
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公开(公告)号：EP2023729A4
公开(公告)日：2010-07-14
申请号：EP07812042
申请日：2007-06-06
发明人： WENNOGLE LAWRENCE P , LI PENG
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00
CPC分类号： C07D487/04
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公开(公告)号：EP3226870A4
公开(公告)日：2018-05-30
申请号：EP15865341
申请日：2015-12-07
发明人： LI PENG , ZHENG HAILIN , SNYDER GRETCHEN , WENNOGLE LAWRENCE P , HENDRICK JOSEPH
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
CPC分类号： A61K31/519 , A61K2300/00 , C07D231/06 , C07D231/54 , C07D403/14 , C07D487/04
摘要： The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.
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