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公开(公告)号：EP2197873A1
公开(公告)日：2010-06-23
申请号：EP08831608.8
申请日：2008-09-03
申请人： IRM LLC
发明人： ALPER, Phillip , AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , JIANG, Songchun , LELAIS, Gerald , MICHELLYS, Pierre-yves , MUTNICK, Daniel , NIKULIN, Victor , WESTCOTT-BAKER, Lucas
IPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048 , A61K31/44 , A61K31/496 , A61K31/4965 , A61P3/10
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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公开(公告)号：EP2114890A2
公开(公告)日：2009-11-11
申请号：EP08713244.5
申请日：2008-01-22
申请人： IRM LLC
发明人： ALPER, Phillip , AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , JIANG, Songchun , LELAIS, Gerald , MICHELLYS, Pierre-Yves , NGUYEN, Truc Ngoc , WESTCOTT-BAKER, Lucas , WU, Baogen
IPC分类号： C07D217/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D487/04 , C07D495/04 , A61K31/4725 , A61P3/10 , A61P3/04
CPC分类号： C07D401/12 , C07D217/08 , C07D401/06 , C07D401/10 , C07D401/14 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D487/04 , C07D495/04
摘要： The invention provides compounds, pharmaceutical compositions comprising compound of following formula (I), and methods of using such compounds to treat or prevent diseases or disorders associated with theactivity of GPR119 (G protein-coupled receptor 119) such as obesity, diabetes and hyperlipidemia.
摘要翻译： 本发明提供了化合物，包含下式（I）化合物的药物组合物，以及使用该化合物治疗或预防与GPR119（G蛋白偶联受体119）活性相关的疾病或病症如肥胖症，糖尿病和高脂血症的方法。
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公开(公告)号：EP2197873B1
公开(公告)日：2014-07-16
申请号：EP08831608.8
申请日：2008-09-03
申请人： IRM LLC
发明人： ALPER, Phillip , AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , JIANG, Songchun , LELAIS, Gerald , MICHELLYS, Pierre-yves , MUTNICK, Daniel , NIKULIN, Victor , WESTCOTT-BAKER, Lucas
IPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048 , A61K31/44 , A61K31/496 , A61K31/4965 , A61P3/10
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
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公开(公告)号：EP2486033A1
公开(公告)日：2012-08-15
申请号：EP10763952.8
申请日：2010-10-01
申请人： IRM LLC
发明人： AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , LELAIS, Gerald , MECOM, John , NIKULIN, Victor
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/14 , A61K31/495 , A61K31/44 , A61P3/10
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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5.发明公开POLYCYCLIC 1,2,3,4-TETRAHYDRO-ISOQUINOLINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS 审中-公开多环芳烃1,2,3,4-四HYDRO-异喹啉衍生物和组合物因此可用作PPAR调节因子
公开(公告)号：EP1979347A2
公开(公告)日：2008-10-15
申请号：EP07717034.8
申请日：2007-01-25
申请人： IRM LLC
发明人： EPPLE, Robert , COW, Christopher
IPC分类号： C07D417/04 , C07D417/06 , C07D417/12 , A61K31/4725 , A61P3/00
CPC分类号： C07D417/04 , C07D417/06 , C07D417/12
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
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公开(公告)号：EP1979355B1
公开(公告)日：2010-08-18
申请号：EP07717085.0
申请日：2007-01-25
申请人： IRM LLC
发明人： EPPLE, Robert , RUSSO, Ross , AZIMIOARA, Mihai , COW, Christopher , MOLTENI, Valentina , LI, Xiaolin , CHIANELLI, Donatella
IPC分类号： C07D471/10 , A61K31/435 , A61P3/00 , A61P9/00 , A61P11/00
CPC分类号： C07D471/10
摘要： The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
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公开(公告)号：EP2121675A1
公开(公告)日：2009-11-25
申请号：EP08705739.4
申请日：2008-01-07
申请人： IRM LLC
发明人： EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
IPC分类号： C07D417/10 , C07D417/14 , A61K31/427 , A61P3/10
CPC分类号： C07D417/10 , C07D417/14
摘要： The invention provides compounds of formula (IA) or (IB) and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 120 (GPR120), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR120.
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8.发明公开
公开(公告)号：EP2076513A1
公开(公告)日：2009-07-08
申请号：EP07844322.3
申请日：2007-10-16
申请人： IRM LLC
发明人： CHIANELLI, Donatella , COW, Christopher , HE, Yun , JIANG, Songchun , LI, Xiaolin , LIU, Xiaodong , LIU, Zuosheng , LOREN, Jon , MOLTENI, Valentina , NABAKKA, Juliet , REN, Pingda , SIM, Taebo , WANG, Xiaodong , YOU, Shuli
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFR , PDGFR , CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF , SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2 , BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
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公开(公告)号：EP1945620A2
公开(公告)日：2008-07-23
申请号：EP06837062.6
申请日：2006-11-07
申请人： IRM LLC
发明人： EPPLE, Robert , COW, Christopher , AZIMIOARA, Mihai , RUSSO, Ross , XIE, Yongping , WANG, Xing
IPC分类号： C07D263/32 , C07D263/46 , C07D277/22 , C07D277/36 , C07D417/12 , A61K31/421 , A61K31/426
CPC分类号： C07D263/32 , C07D263/46 , C07D277/22 , C07D277/36 , C07D417/12
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
摘要翻译： 本发明提供了化合物，包含此类化合物的药物组合物以及使用此类化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族活性有关的疾病或病症的方法。
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公开(公告)号：EP2262496A1
公开(公告)日：2010-12-22
申请号：EP09711737.8
申请日：2009-02-20
申请人： IRM LLC
IPC分类号： A61K31/402 , C07D207/12 , A61P3/00 , C07D403/12
CPC分类号： C07D207/12 , C07D401/12
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译： 本发明提供了化合物，包含这些化合物的药物组合物以及使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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