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公开(公告)号：EP2331503A1
公开(公告)日：2011-06-15
申请号：EP09790229.0
申请日：2009-07-09
申请人： IRM LLC
IPC分类号： C07D211/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D498/04 , A61K31/4523 , A61P3/10
CPC分类号： C07D401/14 , C07D211/30 , C07D401/04 , C07D401/12 , C07D405/14 , C07D498/04
摘要： The present invention provides compounds of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent; diseases or disorders associated with the activity of GPR119.
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公开(公告)号：EP2125758A1
公开(公告)日：2009-12-02
申请号：EP08727424.7
申请日：2008-01-08
申请人： IRM LLC
发明人： EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
IPC分类号： C07D263/32 , C07D263/60 , C07D277/30 , C07D513/04 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/429 , A61P3/00
CPC分类号： C07D263/32 , C07D263/60 , C07D277/30 , C07D513/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 20 (GPR20), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR20.
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公开(公告)号：EP2331503B1
公开(公告)日：2013-08-21
申请号：EP09790229.0
申请日：2009-07-09
申请人： IRM LLC
IPC分类号： C07D211/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D498/04 , A61K31/4523 , A61P3/10
CPC分类号： C07D401/14 , C07D211/30 , C07D401/04 , C07D401/12 , C07D405/14 , C07D498/04
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公开(公告)号：EP2252613A1
公开(公告)日：2010-11-24
申请号：EP09712085.1
申请日：2009-02-20
申请人： IRM, LLC
发明人： AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , JIANG, Songchun , LELAIS, Gerald , MUTNICK, Daniel , WU, Baogen
IPC分类号： C07D471/04 , A61K31/519 , A61K31/4375 , A61P3/00 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译： 本发明提供了式（I）的化合物：包含此类化合物的药物组合物以及使用此类化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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5.发明公开COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR ACTIVITY 有权VERBINDUNGEN UND ZUSAMMENSETZUNGEN ZUR MODULATION DER EGFR-AKTIVITÄT
公开(公告)号：EP2773635A1
公开(公告)日：2014-09-10
申请号：EP13729219.9
申请日：2013-06-05
申请人： IRM LLC
发明人： LELAIS, Gerald , EPPLE, Robert , MARSILJE, III, Thomas H. , MICHELLYS, Pierre-Yves , MCNEILL, Matthew H. , LONG, Yun , LU, Wenshuo , CHEN, Bei , BURSULAYA, Badry , JIANG, Songchun
IPC分类号： C07D401/14 , C07D413/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D513/04 , A61K31/4439
CPC分类号： C07D401/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
摘要翻译： 本发明提供了可用于调节EGFR活性的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调的EGFR活性相关的病症的方法。
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公开(公告)号：EP2134704A1
公开(公告)日：2009-12-23
申请号：EP08731470.4
申请日：2008-03-05
申请人： IRM LLC
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/445 , A61P3/10
CPC分类号： C07D413/14 , C07D401/14 , C07D417/14
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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公开(公告)号：EP2121675A1
公开(公告)日：2009-11-25
申请号：EP08705739.4
申请日：2008-01-07
申请人： IRM LLC
发明人： EPPLE, Robert , AZIMIOARA, Mihai , COW, Christopher , RUSSO, Ross , NIKULIN, Victor , LELAIS, Gerald
IPC分类号： C07D417/10 , C07D417/14 , A61K31/427 , A61P3/10
CPC分类号： C07D417/10 , C07D417/14
摘要： The invention provides compounds of formula (IA) or (IB) and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 120 (GPR120), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR120.
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公开(公告)号：EP2197873B1
公开(公告)日：2014-07-16
申请号：EP08831608.8
申请日：2008-09-03
申请人： IRM LLC
发明人： ALPER, Phillip , AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , JIANG, Songchun , LELAIS, Gerald , MICHELLYS, Pierre-yves , MUTNICK, Daniel , NIKULIN, Victor , WESTCOTT-BAKER, Lucas
IPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048 , A61K31/44 , A61K31/496 , A61K31/4965 , A61P3/10
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
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公开(公告)号：EP2486033A1
公开(公告)日：2012-08-15
申请号：EP10763952.8
申请日：2010-10-01
申请人： IRM LLC
发明人： AZIMIOARA, Mihai , COW, Christopher , EPPLE, Robert , LELAIS, Gerald , MECOM, John , NIKULIN, Victor
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/14 , A61K31/495 , A61K31/44 , A61P3/10
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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公开(公告)号：EP2134704B1
公开(公告)日：2010-09-22
申请号：EP08731470.4
申请日：2008-03-05
申请人： IRM LLC
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , A61K31/445 , A61P3/10
CPC分类号： C07D413/14 , C07D401/14 , C07D417/14
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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