专利检索 ap:("IRM LLC") AND inv:"ALBAUGH, Pamela, A." 第 1 页

1.

发明公开
PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF 审中-公开
标题翻译：蛋白激酶抑制剂及其使用方法

公开(公告)号：EP2170867A1

公开(公告)日：2010-04-07

申请号：EP08770592.7

申请日：2008-06-10

申请人： IRM LLC

发明人： HUANG, Shenlin , LIU, Zuosheng , ALBAUGH, Pamela, A. , WANG, Xing , PAN, Shifeng , XIE, Yongping , ZHANG, Guobao

IPC分类号： C07D401/14 , C07D403/04

CPC分类号： C07D401/14 , C07D403/04

摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, CSK, C-Src, EphB1, EphB2, EphB4, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFRβ, PKCα, SAPK2α, Src, SIK, Syk, Tie2 and TrkB kinases.

2.

发明公开
FUSED NITROGEN CONTAINING HETEROCYCLES AND COMPOSITIONS THEREOF AS KINASE INHIBITORS 有权
标题翻译：冷凝的氮含杂周期和它们的组合物用作激酶抑制剂

公开(公告)号：EP2300469A2

公开(公告)日：2011-03-30

申请号：EP09747213.8

申请日：2009-05-07

申请人： IRM LLC

发明人： ALBAUGH, Pamela, A. , CHOI, Ha-Soon , CHOPIUK, Gregory , FAN, Yi , RUCKER, Paul, Vincent , WANG, Zhicheng

IPC分类号： C07D471/04 , C07D487/04 , A61K31/4985 , A61K31/4353 , A61P37/00

CPC分类号： C07D471/04 , C07D487/04

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Ros, KDR, FMS, c-FMS, FLT3, c-Kit, JAK2, JAK3, Aurora, PDGFR, Lck, TrkA, TrkB, TrkC, IGF-1R, ALK4, ALK5 and ALK or combinations thereof.

3.

发明公开
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：化合物和组合物作为蛋白激酶抑制剂

公开(公告)号：EP1814545A2

公开(公告)日：2007-08-08

申请号：EP05851419.1

申请日：2005-11-07

申请人： IRM, LLC

发明人： WAN, Yongqin , MI, Yuan , FAN, Yi , CHENG, Dai , LIU, Yi , GRAY, Nathanael, Schiander , ALBAUGH, Pamela, A.

IPC分类号： A61K31/4178 , C07D403/14

CPC分类号： C07D403/14 , C07D403/06

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC , Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.