公开(公告)号：EP1594508B1

公开(公告)日：2012-08-08

申请号：EP04710227.2

申请日：2004-02-11

申请人： IRM LLC

发明人： PAN, Shifeng ,  GRAY, Nathanael ,  MI, Yuan ,  GAO, Wenqi ,  FAN, Yi ,  LEFEBVRE, Sophie

IPC分类号： A61K31/537 ,  A61K31/421 ,  A61K31/277 ,  A61K31/15 ,  A61K31/18 ,  A61K31/42

CPC分类号： C07D213/30 ,  C07C251/48 ,  C07C251/52 ,  C07C251/54 ,  C07D307/42 ,  C07D333/16 ,  C07F9/094 ,  C07F9/655345

摘要： The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.

公开(公告)号：EP1628967B1

公开(公告)日：2014-04-09

申请号：EP04752679.3

申请日：2004-05-19

申请人： IRM LLC

发明人： MI, Yuan ,  PAN, Shifeng ,  GRAY, Nathanael, S. ,  GAO, Wenqi ,  FAN, Yi ,  JIANG, Tao

IPC分类号： C07D413/10 ,  A61K31/4725 ,  C07D333/58 ,  C07D409/06 ,  C07D471/04 ,  C07D473/00 ,  C07D261/20 ,  C07D513/04

CPC分类号： C07D333/58 ,  C07D261/20 ,  C07D409/06 ,  C07D471/04 ,  C07D473/00 ,  C07D513/04

公开(公告)号：EP1628967A1

公开(公告)日：2006-03-01

申请号：EP04752679.3

申请日：2004-05-19

申请人： IRM LLC

发明人： MI, Yuan ,  PAN, Shifeng ,  GRAY, Nathanael, S. ,  GAO, Wenqi ,  FAN, Yi ,  JIANG, Tao

IPC分类号： C07D333/60

CPC分类号： C07D333/58 ,  C07D261/20 ,  C07D409/06 ,  C07D471/04 ,  C07D473/00 ,  C07D513/04

摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

公开(公告)号：EP2300469A2

公开(公告)日：2011-03-30

申请号：EP09747213.8

申请日：2009-05-07

申请人： IRM LLC

发明人： ALBAUGH, Pamela, A. ,  CHOI, Ha-Soon ,  CHOPIUK, Gregory ,  FAN, Yi ,  RUCKER, Paul, Vincent ,  WANG, Zhicheng

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/4353 ,  A61P37/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Ros, KDR, FMS, c-FMS, FLT3, c-Kit, JAK2, JAK3, Aurora, PDGFR, Lck, TrkA, TrkB, TrkC, IGF-1R, ALK4, ALK5 and ALK or combinations thereof.

公开(公告)号：EP1511473B8

公开(公告)日：2013-07-24

申请号：EP03730117.3

申请日：2003-05-26

申请人： Novartis AG ,  Novartis Pharma GmbH ,  IRM LLC

发明人： FAN, Yi ,  GAO, Wenqi ,  GRAY, Nathanael, S. ,  HINTERDING, Klaus ,  LEFEBVRE, Sophie ,  MI, Yuan ,  NUSSBAUMER, Peter ,  PAN, Shifeng ,  WANG, Wei ,  ZECRI, Frédéric ,  PEREZ, Lawrence, Blas ,  LA MONTAGNE, Kenneth, Richard ,  ETTMAYER, Peter

IPC分类号： C07C215/28 ,  C07C215/46 ,  C07C217/54 ,  C07C237/30 ,  C07C251/48 ,  C07C255/13 ,  C07C255/43 ,  C07C255/58 ,  C07C311/08 ,  C07D261/08 ,  C07D317/58 ,  C07C333/20 ,  C07F9/09 ,  C07D263/57 ,  C07D333/20

CPC分类号： C07D263/57 ,  C07C215/28 ,  C07C215/46 ,  C07C217/54 ,  C07C237/30 ,  C07C251/48 ,  C07C255/13 ,  C07C255/43 ,  C07C255/58 ,  C07C311/08 ,  C07C2601/02 ,  C07C2601/08 ,  C07D261/08 ,  C07D317/58 ,  C07D333/20 ,  C07F9/094

公开(公告)号：EP2614062A1

公开(公告)日：2013-07-17

申请号：EP11758063.9

申请日：2011-09-09

申请人： IRM LLC

发明人： FAN, Yi ,  LOREN, Jon ,  MOLTENI, Valentina ,  ALBAUGH, Pamela A. ,  CHOPIUK, Gregory ,  SMITH, Jeffrey M. ,  FLATT, Brenton T.

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/4353 ,  A61K31/4985 ,  A61P37/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.

公开(公告)号：EP1917240A1

公开(公告)日：2008-05-07

申请号：EP06813662.1

申请日：2006-08-22

申请人： IRM LLC

发明人： GAO, Wenqi ,  WAN, Yongqin ,  JIANG, Jiqing ,  FAN, Yi ,  GRAY, Nathanael, S. ,  PAN, Shifeng

IPC分类号： C07D209/12 ,  C07D213/79 ,  C07D213/55 ,  C07D213/86 ,  C07D213/81 ,  C07D213/80 ,  C07D213/89 ,  C07D213/84 ,  C07D213/90 ,  C07D239/28 ,  C07D231/12 ,  C07D277/56 ,  C07D241/24 ,  C07D401/06 ,  C07D417/12

CPC分类号： C07D213/79 ,  C07D209/12 ,  C07D213/54 ,  C07D213/80 ,  C07D213/81 ,  C07D213/84 ,  C07D213/86 ,  C07D213/89 ,  C07D231/12 ,  C07D233/90 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D277/56 ,  C07D401/04 ,  C07D401/06 ,  C07D413/04 ,  C07D417/12

摘要： The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. This application relates to compounds selected from Formula (Ia), (Ib), (Ic) and (Id).

公开(公告)号：EP1814545A2

公开(公告)日：2007-08-08

申请号：EP05851419.1

申请日：2005-11-07

申请人： IRM, LLC

发明人： WAN, Yongqin ,  MI, Yuan ,  FAN, Yi ,  CHENG, Dai ,  LIU, Yi ,  GRAY, Nathanael, Schiander ,  ALBAUGH, Pamela, A.

IPC分类号： A61K31/4178 ,  C07D403/14

CPC分类号： C07D403/14 ,  C07D403/06

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC , Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

公开(公告)号：EP1594508A2

公开(公告)日：2005-11-16

申请号：EP04710227.2

申请日：2004-02-11

申请人： IRM LLC

发明人： PAN, Shifeng ,  GRAY, Nathanael ,  MI, Yuan ,  GAO, Wenqi ,  FAN, Yi ,  LEFEBVRE, Sophie

IPC分类号： A61K31/537 ,  A61K31/421 ,  A61K31/277 ,  A61K31/15 ,  A61K31/18 ,  A61K31/42

CPC分类号： C07D213/30 ,  C07C251/48 ,  C07C251/52 ,  C07C251/54 ,  C07D307/42 ,  C07D333/16 ,  C07F9/094 ,  C07F9/655345

摘要： The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.

公开(公告)号：EP2678338A1

公开(公告)日：2014-01-01

申请号：EP12708450.7

申请日：2012-02-23

申请人： IRM LLC

发明人： MOLTENI, Valentina ,  FAN, Yi ,  LOREN, Jon ,  SMITH, Jeffrey M. ,  FLATT, Brenton T.

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  C07D207/09

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.