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    Pharmaceutical compositions containing benzoyl urea derivatives
    3.
    发明公开
    Pharmaceutical compositions containing benzoyl urea derivatives 失效
    Benzoylharnstoff-Derivate enthaltende Arzneimittel。

    公开(公告)号：EP0264904A2

    公开(公告)日：1988-04-27

    申请号：EP87115332.6

    申请日：1987-10-20

    申请人： ISHIHARA SANGYO KAISHA, LTD. ,  GREEN CROSS CORPORATION

    发明人： Kondo, Nobuo ,  Kikuchi, Masahiro ,  Nakajima, Tsunetaka ,  Watanabe, Masahiro ,  Yokoyama, Kazumasa ,  Haga, Takahiro ,  Yamada, Nobutoshi ,  Sugi, Hideo ,  Koyanagi, Toru 3F-410, 151-30, Ninomaru-cho

    IPC分类号： A61K9/14 ,  A61K47/00 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505

    CPC分类号： A61K31/505 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K31/44 ,  A61K31/50 ,  A61K47/14 ,  A61K47/26 ,  Y10S514/961 ,  Y10S514/964

    摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula:
    wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z₁ is a halogen atom or a trifluoromethyl group, Z₂ is a hydrogen atom or a halogen atom, and A is a =CH- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula:
    wherein each of X₁ and X₂ is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X₁ is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.

    摘要翻译： 一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A），其中X是卤素原子，硝基或三氟甲基，条件是当Y 是硝基，X是卤原子或硝基，Y是氢原子，卤素原子，硝基或三氟甲基，Z1是卤素原子或三氟甲基，Z2是氢原子或 卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2分别为氢原子，卤素原子或硝基， 条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤原子，硝基或三氟甲基，Z为氢原子，卤素原子或三氟甲基，作为 有效成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。

    Benzoyl urea compound
    8.
    发明公开
    Benzoyl urea compound 失效
    苯甲酰Harnstoff-Verbindungen。

    公开(公告)号：EP0262560A2

    公开(公告)日：1988-04-06

    申请号：EP87113839.2

    申请日：1987-09-22

    申请人： ISHIHARA SANGYO KAISHA, LTD. ,  GREEN CROSS CORPORATION

    发明人： Kondo, Nobuo ,  Kikuchi, Masahiro ,  Nakajima, Tsunetaka ,  Watanabe, Masahiro ,  Yokoyama, Kazumasa ,  Haga, Takahiro ,  Yamada, Nobutoshi ,  Sugi, Hideo ,  Koyanagi, Toru

    IPC分类号： C07D213/64 ,  C07D239/10 ,  C07D237/14 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505

    CPC分类号： C07D213/643 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  C07D237/14 ,  C07D239/34

    摘要： A benzoyl urea compound having the formula:
    wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z₁ is a halogen atom or a trifluoromethyl group, Z₂ is a hydrogen atom or a halogen atom, and A is a =CH- group or a nitrogen atom, or the formula:
    wherein each of X₁ and X₂ is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X₁ is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, characterized in that its average particle size is not larger than 1 µm.

    摘要翻译： 具有下式的苯甲酰脲化合物，其中X为卤素原子，硝基或三氟甲基，条件是当Y为硝基时，X为卤素原子或硝基，Y为氢原子 卤素原子，硝基或三氟甲基，Z 1为卤素原子或三氟甲基，Z 2为氢原子或卤素原子，A为a = CH-或氮原子，式 其中X1和X2各自为氢原子，卤原子或硝基，条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤素原子，硝基 或三氟甲基，Z为氢原子，卤素原子或三氟甲基，其特征在于其平均粒径为1μm以下。