公开(公告)号：EP1152771A2

公开(公告)日：2001-11-14

申请号：EP00903870.4

申请日：2000-02-17

申请人： ISIS INNOVATION LIMITED

发明人： MACPHERSON, George Gordon,University of Oxford ,  WYKES, Michelle Niloufer,Mater Medical Res. Inst.

IPC分类号： A61K39/39 ,  C12N5/06 ,  C12N5/08 ,  A61K39/00 ,  A61K35/14 ,  C07K14/705 ,  C12N15/12 ,  C07K16/28 ,  G01N33/50 ,  A61P37/04 ,  A61P37/06

CPC分类号： C12N5/064 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/5154 ,  A61K2039/55516 ,  C07K14/70596 ,  C07K2319/00 ,  C12N5/0639

摘要： Use of CD38, or a portion thereof or analogue thereof which can inhibit the binding of CD38 to a non-follicular dendritic cell (DC) or a follicular dendritic cell (FDC) and which retains the ability of CD38 to stimulate a DC or FDC, for use in the manufacture of an adjuvant for use in immunotherapy. Also provided is a method of maturing DCs in vitro and a vaccine comprising mature DCs. The invention also provides a natural ligand of CD38 on FDCs and DCs and inhibitors of the ligand. The inhibitors can be used for immunosuppression.