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1.发明授权
公开(公告)号：EP0763052B1
公开(公告)日：2004-10-27
申请号：EP95922217.5
申请日：1995-05-31
发明人： MONIA, Brett P. , BOGGS, Russell T.
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/00 , C12N15/1135 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3517 , C12N2310/3525 , C12N2310/3527 , C12N2310/3521
摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
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公开(公告)号：EP0763052A1
公开(公告)日：1997-03-19
申请号：EP95922217.0
申请日：1995-05-31
发明人： MONIA, Brett P. , BOGGS, Russell T.
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/00 , C12N15/1135 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3517 , C12N2310/3525 , C12N2310/3527 , C12N2310/3521
摘要： Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.
摘要翻译： 提供了靶向编码人raf并能够抑制raf表达的核酸的寡核苷酸。 在优选的实施方案中，寡核苷酸靶向编码人c-raf或人A-raf的mRNA。 寡核苷酸可以在一个或多个位置具有化学修饰，并且可以是嵌合寡核苷酸。 还提供了使用本发明的寡核苷酸抑制人raf表达的方法。 本发明还包括抑制细胞过度增殖的方法和治疗使用本发明寡核苷酸的异常增殖病症的方法。
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公开(公告)号：EP0714449A1
公开(公告)日：1996-06-05
申请号：EP94923932.0
申请日：1994-07-08
IPC分类号： C12N15 , A61K31 , A61K48 , A61P29 , A61P35 , A61P43 , C07H21 , C07K14 , C12N5 , C12N9 , C12Q1 , G01N33 , A61K38
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C07H21/00 , C07K14/70564 , C12N9/12 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12N2310/3527 , C12N2310/3533 , C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , C12Y207/11013
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with a PKC gene or mRNA. Oligonucleotides specifically hybridizable with a particular PKC isozyme, set of isozymes or mRNA transcript are provided. Methods of treating conditions amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with a PKC gene or mRNA are disclosed. Compositions and methods are provided for the treatment, detection and diagnosis of diseases associated with protein kinase Calpha and specific transcripts thereof. New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase Calpha. Polynucleotide probes for PKCalpha are also disclosed.
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