公开(公告)号：EP0714449A1

公开(公告)日：1996-06-05

申请号：EP94923932.0

申请日：1994-07-08

申请人： ISIS PHARMACEUTICALS, INC.

发明人： BENNETT, C. Frank ,  BOGGS, Russell T. ,  DEAN, Nicholas M.

IPC分类号： C12N15 ,  A61K31 ,  A61K48 ,  A61P29 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K14 ,  C12N5 ,  C12N9 ,  C12Q1 ,  G01N33 ,  A61K38

CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/70564 ,  C12N9/12 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y207/11013

摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with a PKC gene or mRNA. Oligonucleotides specifically hybridizable with a particular PKC isozyme, set of isozymes or mRNA transcript are provided. Methods of treating conditions amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with a PKC gene or mRNA are disclosed. Compositions and methods are provided for the treatment, detection and diagnosis of diseases associated with protein kinase Calpha and specific transcripts thereof. New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase Calpha. Polynucleotide probes for PKCalpha are also disclosed.