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公开(公告)号：EP0804456A1
公开(公告)日：1997-11-05
申请号：EP95938726.0
申请日：1995-10-06
发明人： NIELSEN, Peter , EGHOLM, Michael , BUCHARDT, Ole +di , SONNECHSEN, Soren, Holst , LOHSE, Jesper , MANOHARAN, Muthiah , KIELY, John , GRIFFITH, Michael , SPRANKLE, Kelly
CPC分类号： C07K14/003
摘要： A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
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公开(公告)号：EP0804456B1
公开(公告)日：2002-08-21
申请号：EP95938726.7
申请日：1995-10-06
发明人： NIELSEN, Peter , EGHOLM, Michael , BUCHARDT, Ole +di , SONNECHSEN, Soren, Holst , LOHSE, Jesper , MANOHARAN, Muthiah , KIELY, John , GRIFFITH, Michael , SPRANKLE, Kelly
CPC分类号： C07K14/003
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公开(公告)号：EP0777678A1
公开(公告)日：1997-06-11
申请号：EP95911848.0
申请日：1995-02-22
发明人： COOK, Philip Dan , KIELY, John , SPRANKLE, Kelly
CPC分类号： C07K14/003 , B01J2219/00592 , B01J2219/00729 , C07K7/02
摘要： New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are methods of making random libraries of peptide nucleic acids using the fully preformed monomers.
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公开(公告)号：EP0777678B1
公开(公告)日：1999-10-13
申请号：EP95911848.0
申请日：1995-02-22
发明人： COOK, Phillip Dan , KIELY, John , SPRANKLE, Kelly
CPC分类号： C07K14/003 , B01J2219/00592 , B01J2219/00729 , C07K7/02
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