-
公开(公告)号：EP0804456B1
公开(公告)日：2002-08-21
申请号：EP95938726.7
申请日：1995-10-06
发明人： NIELSEN, Peter , EGHOLM, Michael , BUCHARDT, Ole +di , SONNECHSEN, Soren, Holst , LOHSE, Jesper , MANOHARAN, Muthiah , KIELY, John , GRIFFITH, Michael , SPRANKLE, Kelly
CPC分类号： C07K14/003
-
公开(公告)号：EP0773950A1
公开(公告)日：1997-05-21
申请号：EP95928084.0
申请日：1995-07-13
申请人： ISIS PHARMACEUTICALS, INC. , PERSEPTIVE BIOSYSTEMS, INC. , BUCHARDT, Dorte , EGHOLM, Michael , NIELSEN, Peter Eigil
发明人： EGHOLM, Michael , NIELSEN, Peter , BUCHARDT, Ole , DUEHOLM, Kim, L. , CHRISTENSEN, Leif , COULL, James, M. , KIELY, John , GRIFFITH, Michael
IPC分类号： C12N15 , A61K31 , A61K38 , A61K47 , A61K48 , A61P31 , A61P35 , A61P43 , C07H21 , C07K1 , C07K5 , C07K7 , C07K14 , C12Q1
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2525/107 , C12Q2537/119 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
-
公开(公告)号：EP0773950B1
公开(公告)日：2007-08-22
申请号：EP95928084.3
申请日：1995-07-13
申请人： ISIS PHARMACEUTICALS, INC. , PERSEPTIVE BIOSYSTEMS, INC. , BUCHARDT, Dorte , EGHOLM, Michael , NIELSEN, Peter Eigil
发明人： EGHOLM, Michael , NIELSEN, Peter , BUCHARDT, Ole , DUEHOLM, Kim, L. , CHRISTENSEN, Leif , COULL, James, M. , KIELY, John , GRIFFITH, Michael
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2525/107 , C12Q2537/119 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
-
公开(公告)号：EP0777678B1
公开(公告)日：1999-10-13
申请号：EP95911848.0
申请日：1995-02-22
发明人： COOK, Phillip Dan , KIELY, John , SPRANKLE, Kelly
CPC分类号： C07K14/003 , B01J2219/00592 , B01J2219/00729 , C07K7/02
-
公开(公告)号：EP0804456A1
公开(公告)日：1997-11-05
申请号：EP95938726.0
申请日：1995-10-06
发明人： NIELSEN, Peter , EGHOLM, Michael , BUCHARDT, Ole +di , SONNECHSEN, Soren, Holst , LOHSE, Jesper , MANOHARAN, Muthiah , KIELY, John , GRIFFITH, Michael , SPRANKLE, Kelly
CPC分类号： C07K14/003
摘要： A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
-
公开(公告)号：EP0777678A1
公开(公告)日：1997-06-11
申请号：EP95911848.0
申请日：1995-02-22
发明人： COOK, Philip Dan , KIELY, John , SPRANKLE, Kelly
CPC分类号： C07K14/003 , B01J2219/00592 , B01J2219/00729 , C07K7/02
摘要： New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid oligomers as well as random sequence peptide nucleic acid oligomers. Further these methods also provide for the incorporation of peptide nucleic acid units or strings of such units with amino acids or strings of amino acids in chimeric peptide nucleic acid-amino acid compounds. Further disclosed are methods of making random libraries of peptide nucleic acids using the fully preformed monomers.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.021 秒)
