专利检索 ap:("ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.") AND inv:"FINOTTO, Marco" 第 1 页

1.

发明授权
A METHOD TO MAKE A PEPTIDE-CARRIER CONJUGATE WITH A HIGH IMMUNOGENICITY 有权
标题翻译：用于生产肽载体结合体与高免疫原性

公开(公告)号：EP1704167B1

公开(公告)日：2011-01-12

申请号：EP04820430.9

申请日：2004-12-10

申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.

发明人： BIANCHI, Elisabetta , FINOTTO, Marco , INGALLINELLA, Paolo , PESSI, Antonello

IPC分类号： C07K19/00 , C07K14/16 , C07K14/11 , A61K39/12 , G01N33/68

CPC分类号： C07K14/005 , C12N2740/16122 , C12N2760/16122

摘要： The present invention provides a method for making a peptide-carrier conjugate. The method comprises modifying a first peptide to produce a second peptide so that the pI of the second peptide is in a favorable range or closer to the range than the pI of the first peptide, and conjugating a plurality of the second peptide to OMPC to obtain a peptide-carrier conjugate. The peptide load, or the solubility of the conjugate, or both of them are increased by the modification.

2.

发明公开
A METHOD TO MAKE A PEPTIDE-CARRIER CONJUGATE WITH A HIGH IMMUNOGENICITY 有权
标题翻译：用于生产肽载体结合体与高免疫原性

公开(公告)号：EP1704167A1

公开(公告)日：2006-09-27

申请号：EP04820430.9

申请日：2004-12-10

申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.

发明人： BIANCHI, Elisabetta , FINOTTO, Marco , INGALLINELLA, Paolo , PESSI, Antonello

IPC分类号： C07K19/00 , C07K14/16 , C07K14/11 , A61K39/12 , G01N33/68

CPC分类号： C07K14/005 , C12N2740/16122 , C12N2760/16122

摘要： The present invention provides a method for making a peptide-carrier conjugate. The method comprises modifying a first peptide to produce a second peptide so that the pI of the second peptide is in a favorable range or closer to the range than the pI of the first peptide, and conjugating a plurality of the second peptide to OMPC to obtain a peptide-carrier conjugate. The peptide load, or the solubility of the conjugate, or both of them are increased by the modification.