公开(公告)号：EP1364064B1

公开(公告)日：2012-08-01

申请号：EP02709785.6

申请日：2002-03-04

申请人： Ibis Biosciences, Inc.

发明人： ECKER, David, J. ,  GRIFFEY, Richard, H. ,  SAMPATH, Rangarajan ,  HOFSTADLER, Steven ,  MCNEIL, John

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2565/627

摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a 'base composition signature' (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.

公开(公告)号：EP1573065B1

公开(公告)日：2010-09-08

申请号：EP03810055.8

申请日：2003-12-05

申请人： Ibis Biosciences, Inc.

发明人： ECKER, David, J. ,  CROOKE, Stanley, T. ,  BLYN, Lawrence, B. ,  HALL, Thomas, A. ,  JIANG, Yun ,  GRIFFEY, Richard, H. ,  SAMPATH, Rangarajan ,  HOFSTADLER, Steven, A. ,  MCNEIL, John ,  HANNIS, James, C. ,  WHITE, Neill ,  SAMANT, Vivek ,  ESHOO, Mark, W. ,  DRADER, Jared, J.

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6858 ,  C12Q1/6872 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q2600/156 ,  G01N2333/28 ,  G01N2333/32 ,  G01N2333/35 ,  G01N2333/36 ,  C12Q2563/167 ,  C12Q2545/101 ,  C12Q2531/113 ,  C12Q2565/627 ,  C12Q2545/113

摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.