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公开(公告)号：EP3194374A1
公开(公告)日：2017-07-26
申请号：EP15763321.5
申请日：2015-09-14
IPC分类号： C07D249/04 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/4192 , A61P9/00 , A61P35/00
CPC分类号： C07D249/04 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
摘要翻译： 本发明涉及其中X，Y，R 1，R 2，（R 4）n和（R 5）m如说明书中所定义的式（I）化合物及其可药用盐。 这些化合物可用作钙通道阻滞剂。
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公开(公告)号：EP3152199B1
公开(公告)日：2018-08-15
申请号：EP15728640.2
申请日：2015-06-02
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/40 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61K31/415 , A61K31/4155 , A61K31/4439 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P35/00
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04
摘要： wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
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公开(公告)号：EP4143165A1
公开(公告)日：2023-03-08
申请号：EP21721515.1
申请日：2021-04-27
发明人： BEZENCON, Olivier , DEYMIER, Caroline , PETERS, Jens-Uwe , SIEGRIST, Romain , SURIVET, Jean-Philippe
IPC分类号： C07D213/16 , C07D239/24 , C07C275/26 , A61P25/00 , A61K31/505 , A61K31/44
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公开(公告)号：EP3119780B1
公开(公告)日：2018-08-29
申请号：EP15714032.8
申请日：2015-03-17
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , A61K31/435
摘要： wherein R1 and R2 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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公开(公告)号：EP3350179A1
公开(公告)日：2018-07-25
申请号：EP16769914.9
申请日：2016-09-14
发明人： AISSAOUI, Hamed , BOSS, Christoph , BOUIS, Patrick , HAZEMANN, Julien , SIEGRIST, Romain , VON RAUMER, Markus
IPC分类号： C07D471/04 , A61K31/506 , A61P37/00
CPC分类号： C07D471/04
摘要： The invention relates to a crystalline form of (S)-2-(8-((5-chloropyrimidin-2-yl)(methyl)amino)- 2-fluoro-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-5-yl)acetic acid, processes for the preparation thereof, pharmaceutical compositions comprising said crystalline forms, pharmaceutical compositions prepared from such crystalline forms, and their use as a medicament, especially as CRTH2 receptor modulators.
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公开(公告)号：EP4172140A1
公开(公告)日：2023-05-03
申请号：EP21734848.1
申请日：2021-06-24
发明人： BEZENCON, Olivier , DEYMIER, Caroline , PETERS, Jens-Uwe , SIEGRIST, Romain , SURIVET, Jean-Philippe
IPC分类号： C07C275/26 , C07D213/64 , C07D239/34 , A61P25/00
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公开(公告)号：EP3194374B1
公开(公告)日：2018-08-01
申请号：EP15763321.5
申请日：2015-09-14
IPC分类号： C07D249/04 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/4192 , A61P9/00 , A61P35/00
CPC分类号： C07D249/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D471/04
摘要： The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.
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公开(公告)号：EP3119779B1
公开(公告)日：2018-07-11
申请号：EP15714030.2
申请日：2015-03-16
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： wherein R1 and R2 are as described in the description, and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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公开(公告)号：EP2970217B1
公开(公告)日：2017-08-09
申请号：EP14715428.0
申请日：2014-03-14
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D213/75 , C07D401/12 , C07D417/14 , C07D471/04 , C07D211/58 , A61K31/435 , A61K31/445
CPC分类号： C07D401/12 , C07D211/58 , C07D213/75 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D471/04
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