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公开(公告)号：EP2906553B1
公开(公告)日：2019-06-26
申请号：EP13805561.1
申请日：2013-10-09
发明人： BOLLI, Martin , BOSS, Christoph , BROTSCHI, Christine , GUDE, Markus , HEIDMANN, Bibia , SIFFERLEN, Thierry , WILLIAMS, Jodi T.
IPC分类号： C07D401/14 , C07D413/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D419/04 , C07D419/14 , A61K31/41 , A61P25/00
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公开(公告)号：EP3625222A1
公开(公告)日：2020-03-25
申请号：EP18725222.6
申请日：2018-05-17
发明人： BOSS, Christoph , CORMINBOEUF, Olivier , FRETZ, Heinz , LYOTHIER, Isabelle , POZZI, Davide , RICHARD-BILDSTEIN, Sylvia , SIENDT, Hervé , SIFFERLEN, Thierry
IPC分类号： C07D403/04 , C07D239/42 , C07D409/04 , C07D413/04 , A61P35/00 , A61K31/506
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公开(公告)号：EP2608787B1
公开(公告)日：2019-11-20
申请号：EP11758563.8
申请日：2011-08-23
发明人： BOSS, Christoph , BROTSCHI, Christine , GATFIELD, John , GUDE, Markus , HEIDMANN, Bibia , SIFFERLEN, Thierry , WILLIAMS, Jodi T.
IPC分类号： A61K31/401 , A61K31/4025 , A61P39/00 , A61P25/30 , A61P25/00 , A61P3/00 , C07D207/48
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公开(公告)号：EP3928836A1
公开(公告)日：2021-12-29
申请号：EP21186831.0
申请日：2016-11-17
发明人： FRETZ, Heinz , LYOTHIER, Isabelle , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , SIFFERLEN, Thierry , WYDER PETERS, Lorenza , POZZI, Davide , CORMINBOEUF, Olivier
IPC分类号： A61P35/00 , A61K31/506
摘要： The present invention relates to derivatives of formula (I)
wherein (R 1 ) n , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b and Ar 1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.-
公开(公告)号：EP3625227A1
公开(公告)日：2020-03-25
申请号：EP18725497.4
申请日：2018-05-17
发明人： BOSS, Christoph , CORMINBOEUF, Olivier , FRETZ, Heinz , LYOTHIER, Isabelle , POZZI, Davide , RICHARD-BILDSTEIN, Sylvia , SIENDT, Herv , SIFFERLEN, Thierry
IPC分类号： C07D413/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/14 , A61P35/00 , A61K31/506
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公开(公告)号：EP3625224A1
公开(公告)日：2020-03-25
申请号：EP18725223.4
申请日：2018-05-17
发明人： FRETZ, Heinz , LYOTHIER, Isabelle , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , SIFFERLEN, Thierry
IPC分类号： C07D403/12 , A61P35/00 , A61K31/675
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公开(公告)号：EP3625223A1
公开(公告)日：2020-03-25
申请号：EP18725219.2
申请日：2018-05-17
发明人： BOSS, Christoph , CORMINBOEUF, Olivier , FRETZ, Heinz , LYOTHIER, Isabelle , POZZI, Davide , RICHARD-BILDSTEIN, Sylvia , SIENDT, Herv , SIFFERLEN, Thierry
IPC分类号： C07D403/12 , C07D403/10 , C07D405/12 , C07D239/42 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/10 , A61K31/506 , A61P35/00
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公开(公告)号：EP3377483A1
公开(公告)日：2018-09-26
申请号：EP16797577.0
申请日：2016-11-17
发明人： FRETZ, Heinz , LYOTHIER, Isabelle , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , SIFFERLEN, Thierry , WYDER PETERS, Lorenza , POZZI, Davide , CORMINBOEUF, Olivier
IPC分类号： C07D403/12 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , A61K31/506 , A61P35/00 , A61P25/00 , A61P9/00 , A61P11/00 , A61P15/00
CPC分类号： C07D413/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to derivativesof formula (I) wherein (R1)n, R2, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
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公开(公告)号：EP3077391B1
公开(公告)日：2018-08-15
申请号：EP14827273.5
申请日：2014-12-03
发明人： BOSS, Christoph , ROCH, Catherine , BROTSCHI, Christine , GUDE, Markus , HEIDMANN, Bibia , JENCK, Francois , SIFFERLEN, Thierry , STEINER, Michel , WILLIAMS, Jodi, T.
IPC分类号： C07D403/14 , A61K31/4178 , A61K31/4192 , A61K31/506 , A61P25/00
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4192 , A61K31/506
摘要： The present invention relates to compounds of the formula (I), wherein Ar1 and Ar2 are as described in the description and to their use as pharmaceuticals for the treatment of sundown syndrome. The invention also relates to the preparation of such compounds and of pharmaceutically acceptable salts thereof.
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10.发明授权CRYSTALLINE SALT FORM OF (S)-(2-(6-CHLORO-7-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)-2-METHYLPYRROLIDIN-1-YL)(5-METHOXY-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)METHANONE AS OREXIN RECEPTOR ANTAGONIST 有权（S） - （2-（6-氯-7-甲基-1H-苯并[d]咪唑-2-基）-2-甲基吡咯烷-1-基）（5-甲氧基-2-（2H- -1,2,3-三唑-2-基）苯基）甲酮作为黄素受体拮抗剂
公开(公告)号：EP3077390B1
公开(公告)日：2017-09-13
申请号：EP14824108.6
申请日：2014-12-02
发明人： BOSS, Christoph , BROTSCHI, Christine , GUDE, Markus , HEIDMANN, Bibia , SIFFERLEN, Thierry , VON RAUMER, Markus , WILLIAMS, Jodi T.
IPC分类号： C07D403/14 , A61K31/4192 , A61P25/00
CPC分类号： C07D403/14 , C07B2200/13
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