公开(公告)号：EP2426114A1

公开(公告)日：2012-03-07

申请号：EP10769860.7

申请日：2010-04-30

申请人： Ihara Chemical Industry Co., Ltd.

发明人： NAKAMURA, Takayuki ,  KUMAGAI, Hironobu ,  OGAWA, Mahito

IPC分类号： C07D275/02

CPC分类号： C07D275/02 ,  C07D275/03

摘要： A process for producing 3,4-dichloro-5-cyanoisothiazole represented by a general formula (3):

the process comprising:
reacting a nitrile compound represented by a general formula (1):

(wherein "n" denotes an integer of 0 to 2), with sulfur chloride represented by a general formula (2):

        [Chemical Formula 18] S m Cl 2      (2)

(wherein "m" represents an integer of 1 to 2), or a mixture thereof in an aprotic polar solvent. There is provided a process for producing 3,4-dichloro-5-cyanoisothiazole, which is capable of suppressing by-production of a waste, without using a raw material having a having a strong toxicity; and is capable of providing a product having a higher purity in a high yield and efficiency in an industrial scale, in a simple manner.

摘要翻译： 由通式（3）表示的3,4-二氯-5-氰基异噻唑的制备方法：该方法包括：使由通式（1）表示的腈化合物：（其中“n”表示0至 （2）表示的氯化硫：[化18] SmCl 2（2）（式中，m表示1〜2的整数）或它们的混合物在非质子性极性溶剂中进行反应。 本发明提供一种不使用具有强毒性的原料而能够抑制废弃物的副产物的3,4-二氯-5-氰基异噻唑的制造方法， 并且能够以简单的方式在工业规模上以高产率和高效率提供具有更高纯度的产品。

公开(公告)号：EP3015451A1

公开(公告)日：2016-05-04

申请号：EP14817123.4

申请日：2014-06-03

申请人： Ihara Chemical Industry Co., Ltd.

发明人： IKUMI, Akiko ,  NAKAMURA, Takayuki

IPC分类号： C07C201/06 ,  C07C205/12 ,  C07C205/58 ,  C07B61/00

CPC分类号： C07C201/10 ,  C07C205/58 ,  C07C205/12

摘要： The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general formula (1):

(in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom, etc.; and R 5 represents a halogen atom or alkoxy carbonyl group), the method including the following processes: (i) a process for reacting aniline compounds of general formula (2):

(in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as previously defined.) in the presence of a metal salt of nitrous acid and an acid, and (ii) a process for reacting the product of process (i) in the presence of a metal salt of nitrous acid and a copper compound; and the total amount of water used in process (ii) being 1.2-2.2 L (liters) with respect to one mole of the compound of general formula (2).

摘要翻译： 本发明的目的是提供一种经济上有利的工业化合适的制备通式（1）的硝基苯化合物的方法。 制备通式（1）的硝基苯化合物的方法：（式中，R 1表示卤素原子; R 2，R 3和R 4表示氢原子等; R 5表示卤素原子或 烷氧基羰基），该方法包括以下方法：（i）使通式（2）的苯胺化合物反应的方法：（式中，R 1，R 2，R 3，R 4和R 5为 （ii）在亚硝酸金属盐和铜化合物的存在下使方法（i）的产物反应的方法;和（ii）使方法（i）的产物在亚硝酸金属盐和铜化合物的存在下反应的方法; 并且相对于1摩尔通式（2）的化合物，方法（ii）中使用的水的总量为1.2-2.2L（升）。

公开(公告)号：EP2426114B1

公开(公告)日：2013-11-20

申请号：EP10769860.7

申请日：2010-04-30

申请人： Ihara Chemical Industry Co., Ltd.

发明人： NAKAMURA, Takayuki ,  KUMAGAI, Hironobu ,  OGAWA, Mahito

IPC分类号： C07D275/02

CPC分类号： C07D275/02 ,  C07D275/03

摘要： A process for producing 3,4-dichloro-5-cyanoisothiazole represented by a general formula (3): the process comprising: reacting a nitrile compound represented by a general formula (1): (wherein "n" denotes an integer of 0 to 2), with sulfur chloride represented by a general formula (2): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ[Chemical Formula 18] S m Cl 2 €ƒ€ƒ€ƒ€ƒ€ƒ(2) (wherein "m" represents an integer of 1 to 2), or a mixture thereof in an aprotic polar solvent. There is provided a process for producing 3,4-dichloro-5-cyanoisothiazole, which is capable of suppressing by-production of a waste, without using a raw material having a having a strong toxicity; and is capable of providing a product having a higher purity in a high yield and efficiency in an industrial scale, in a simple manner.

摘要翻译： 由通式（3）表示的3,4-二氯-5-氰基异噻唑的制备方法：该方法包括：使由通式（1）表示的腈化合物：（其中“n”表示0至 2）与通式（2）表示的氯化硫反应：[化学式18] S Cl 2 ... （2）（式中，“m”表示1〜2的整数）或其混合物在非质子性极性溶剂中进行。 本发明提供一种不使用具有强毒性的原料而能够抑制废弃物的副产物的3,4-二氯-5-氰基异噻唑的制造方法， 并且能够以简单的方式在工业规模上以高产率和高效率提供具有更高纯度的产品。