公开(公告)号：EP4084906A1

公开(公告)日：2022-11-09

申请号：EP20911098.0

申请日：2020-12-18

申请人： Illumina Inc

发明人： CRIVELLI, Paul ,  DELATTRE, Cyril ,  KREINDL, Gerald ,  COX-MURANAMI, Wesley, A. ,  CRANE, Bryan

IPC分类号： B01L3/00

公开(公告)号：EP2362930B1

公开(公告)日：2016-04-06

申请号：EP09829798.9

申请日：2009-11-25

申请人： Illumina, Inc. ,  The Arizona Board of Regents for and on behalf of Arizona State University

发明人： POSNER, Jonathan ,  SALLOUM, Kamil ,  LEBL, Michal ,  REED, Mark ,  BUERMANN, Dale ,  HAGE, Matthew ,  CRANE, Bryan ,  HEINER, David ,  KAIN, Robert

IPC分类号： F04B19/00

CPC分类号： F04B37/10 ,  F04B19/00 ,  Y10T436/2575

公开(公告)号：EP2663402A1

公开(公告)日：2013-11-20

申请号：EP11791076.0

申请日：2011-10-21

申请人： Illumina, Inc.

发明人： REED, Mark T. ,  WILLIAMSON, Erik ,  CRANE, Bryan ,  LEUNG, Patrick ,  BUERMANN, Dale ,  KINDWALL, Alexander P. ,  ERIE, Frederick ,  PRATT, Mark ,  HARRIS, Jason ,  CARSON, Andrew James ,  HONG, Stanley S. ,  BRYANT, Jason ,  WANG, Mark ,  VERKADE, Drew

IPC分类号： B01L3/00 ,  B01L9/00

CPC分类号： B01L3/502715 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2300/022 ,  B01L2300/041 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2300/0877 ,  G01N21/05 ,  G01N2021/058 ,  Y10T436/25

摘要： A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

公开(公告)号：EP4219012A1

公开(公告)日：2023-08-02

申请号：EP23167200.7

申请日：2013-02-13

申请人： Illumina, Inc.

发明人： BUERMANN, Dale ,  CRANE, Bryan ,  HAGE, Matthew ,  HARRIS, Jason ,  HONG, Stanley S. ,  MOON, John A. ,  NIBBE, Mark J. ,  WANG, Mark

IPC分类号： B01L3/00 ,  G01N21/64 ,  C12Q1/6874 ,  G01N21/03 ,  G01N21/05

摘要： A method of imaging a substrate comprising fluorescent features on a surface is described. The surface is imaged using a read head (150) including a plurality of microfluorometers positioned to simultaneously acquire a plurality of wide-field images of a first portion of the surface, wherein each microfluorometer acquires a wide-field image from a different location of the surface and wherein the field diameter of an individual microfluorometer is at least 1 mm. The microfluorometers are affixed to a carriage which is translated in a direction parallel to the surface to acquire a further plurality of wide-field images of a second portion of the surface. The method may be applied as a detection operation in the context of a nucleic acid sequencing procedure, wherein fluidic operations of the nucleic acid sequencing procedure are performed in a fluidic cartridge.

公开(公告)号：EP2362930A2

公开(公告)日：2011-09-07

申请号：EP09829798.9

申请日：2009-11-25

申请人： Illumina, Inc. ,  The Arizona Board of Regents for and on behalf of Arizona State University

发明人： POSNER, Jonathan ,  SALLOUM, Kamil ,  LEBL, Michal ,  REED, Mark ,  BUERMANN, Dale ,  HAGE, Matthew ,  CRANE, Bryan ,  HEINER, David ,  KAIN, Robert

IPC分类号： F04B19/00 ,  F04B37/00 ,  F04B37/10

CPC分类号： F04B37/10 ,  F04B19/00 ,  Y10T436/2575

摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.

公开(公告)号：EP2362930B8

公开(公告)日：2016-05-18

申请号：EP09829798.9

申请日：2009-11-25

申请人： Illumina, Inc. ,  The Arizona Board of Regents for and on behalf of Arizona State University

发明人： POSNER, Jonathan ,  SALLOUM, Kamil ,  LEBL, Michal ,  REED, Mark ,  BUERMANN, Dale ,  HAGE, Matthew ,  CRANE, Bryan ,  HEINER, David ,  KAIN, Robert

IPC分类号： F04B19/00

CPC分类号： F04B37/10 ,  F04B19/00 ,  Y10T436/2575

公开(公告)号：EP2834622A1

公开(公告)日：2015-02-11

申请号：EP13710114.3

申请日：2013-02-13

申请人： Illumina, Inc.

发明人： BUERMANN, Dale ,  MOON, John A. ,  CRANE, Bryan ,  WANG, Mark ,  HONG, Stanley S. ,  HARRIS, Jason ,  HAGE, Matthew ,  NIBBE, Mark J.

IPC分类号： G01N21/64 ,  G01N21/03 ,  G01N21/05

CPC分类号： B01L3/527 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/06 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/0307 ,  G01N2021/0325 ,  G01N2021/058 ,  G01N2021/6417 ,  G01N2021/6441 ,  G01N2021/6482

摘要： A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.