公开(公告)号：EP2654782A2

公开(公告)日：2013-10-30

申请号：EP11852177.2

申请日：2011-12-20

申请人： Immport Therapeutics, INC.

发明人： DAVIES, David Huw ,  LIANG, Xiaowu ,  FELGNER, Philip

IPC分类号： A61K39/012 ,  A61K39/00

CPC分类号： C07K14/45 ,  A61K39/002 ,  G01N33/56905

摘要： Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen
T. gondii and their use in various diagnostic tests, vaccines, and therapeutic agents. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.

公开(公告)号：EP2087128A2

公开(公告)日：2009-08-12

申请号：EP07874107.1

申请日：2007-11-01

申请人： Immport Therapeutics, INC.

发明人： FELGNER, Philip ,  DAVIES, David, Huw ,  LIANG, Xiaowu

IPC分类号： C12P21/06 ,  C07H21/04

CPC分类号： C12N15/1068 ,  A61K39/015 ,  A61K39/0208 ,  A61K39/0225 ,  A61K39/04 ,  A61K39/098 ,  A61K39/118 ,  A61K39/12 ,  A61K39/245 ,  A61K39/285 ,  A61K39/385 ,  A61K2039/60 ,  C07K14/005 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/24122 ,  C12N2710/24134 ,  G01N33/566 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56927 ,  G01N33/5695 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/6854 ,  G01N2333/35 ,  G01N2469/20 ,  Y02A50/401 ,  Y02A50/412

摘要： Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.

摘要翻译： 所考虑的组合物，装置和方法包括来自选定的人病原体（类鼻疽伯克霍尔德氏菌，伯氏疏螺旋体，布鲁氏菌，布氏菌，布氏菌，布氏梭菌，布氏梭菌，土拉弗朗西斯菌，人疱疹病毒1和2，结核分枝杆菌，恶性疟原虫和痘苗病毒）的免疫显性抗原， 可以用作疫苗，作为诊断标记物和作为治疗剂。 在特别优选的方面，抗原对被病原体感染的群体的血清具有定量和已知的相对反应性，并且与疾病参数具有已知的相关性。

公开(公告)号：EP2931306A1

公开(公告)日：2015-10-21

申请号：EP13812436.7

申请日：2013-12-12

申请人： The Regents of the University of California ,  Immport Therapeutics, INC. ,  Yale University

发明人： FELGNER, Philip ,  LIANG, Xiaowu ,  KO, Albert ,  WUNDER, Elsio, A., Jr.

IPC分类号： A61K39/02 ,  C07K14/20

CPC分类号： A61K39/0225 ,  C07K14/20 ,  G01N33/56911 ,  G01N2333/20 ,  G01N2469/20 ,  G01N2800/26 ,  Y02A50/48

摘要： Novel immunodominant antigenic proteins and peptides associated with associated with leptospirosis were identified using a proteome array based on expression of ORFs from a Leptospira genome. Compositions, methods, and uses of such antigenic proteins and peptides in the diagnosis and staging of leptospirosis infection and in compositions, methods, and uses of such antigenic is proteins and peptides in prophylactic and therapeutic vaccines are disclosed.

公开(公告)号：EP2726102A2

公开(公告)日：2014-05-07

申请号：EP12806874.9

申请日：2012-06-29

申请人： Immport Therapeutics, INC.

发明人： DAVIES, David Huw ,  LIANG, Xiaowu ,  FELGNER, Philip

IPC分类号： A61K39/395 ,  A61P31/12 ,  A61P31/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16633 ,  C12N2710/16634 ,  G01N33/549 ,  G01N2333/035

摘要： Contemplated compositions, devices, and methods are drawn to various antigens from Herpes Simplex Virus type 1 (HSV-1) and Herpes Simplex Virus type 2 (HSV-2) and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.