公开(公告)号：EP3411119A1

公开(公告)日：2018-12-12

申请号：EP17748119.9

申请日：2017-02-02

申请人： Immunolight, LLC. ,  Duke University ,  North Carolina State University

发明人： WALDER, Harold ,  BOURKE, Frederic A., Jr. ,  FATHI, Zakaryae ,  BEYER, Wayne ,  OLDHAM, Mark ,  ADAMSON, Justus ,  NOLAN, Michael

IPC分类号： A61N5/10 ,  A61K41/00 ,  A61K49/04

CPC分类号： A61N5/10 ,  A61K41/0066 ,  A61N5/062 ,  A61N2005/0661 ,  A61N2005/1098

摘要： A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+and (3Ca3 (PO4)2Ca(F, CI)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.

公开(公告)号：EP4164631A1

公开(公告)日：2023-04-19

申请号：EP21825169.2

申请日：2021-06-07

申请人： Immunolight, LLC.

发明人： BOURKE, Frederic A., Jr. ,  WALDER, Harold ,  FATHI, Zakaryae

IPC分类号： A61K31/37 ,  A61K31/409 ,  A61K39/00 ,  A61K41/00 ,  A61K45/06 ,  A61K49/00

公开(公告)号：EP2970607B1

公开(公告)日：2019-11-27

申请号：EP14763843.1

申请日：2014-03-14

申请人： Immunolight, LLC.

发明人： BOURKE, Frederic A., Jr. ,  FATHI, Zakaryae ,  WALDER, Harold ,  BEYER, Wayne, F.

IPC分类号： A61N5/06 ,  G03F7/20 ,  A23L3/26 ,  A23L3/28 ,  A61M1/36 ,  A61L2/00 ,  A61L2/08 ,  C02F1/30 ,  C02F1/32

公开(公告)号：EP2970607A2

公开(公告)日：2016-01-20

申请号：EP14763843.1

申请日：2014-03-14

申请人： Immunolight, LLC.

发明人： BOURKE, Frederic A., Jr. ,  FATHI, Zakaryae ,  WALDER, Harold ,  BEYER, Wayne, F.

IPC分类号： C08J3/28

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

摘要翻译： 一种用于产生介质变化的方法和系统。 该方法在介质附近放置能量调节剂。 该方法向介质施加起始能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 能量调节剂具有在已知产生变化的第二波长范围（WR2）之外的第一波长范围内的辐射的正常主要发射，但是在暴露于施加的引发能量的同时产生变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。