公开(公告)号：EP3411119A1

公开(公告)日：2018-12-12

申请号：EP17748119.9

申请日：2017-02-02

申请人： Immunolight, LLC. ,  Duke University ,  North Carolina State University

发明人： WALDER, Harold ,  BOURKE, Frederic A., Jr. ,  FATHI, Zakaryae ,  BEYER, Wayne ,  OLDHAM, Mark ,  ADAMSON, Justus ,  NOLAN, Michael

IPC分类号： A61N5/10 ,  A61K41/00 ,  A61K49/04

CPC分类号： A61N5/10 ,  A61K41/0066 ,  A61N5/062 ,  A61N2005/0661 ,  A61N2005/1098

摘要： A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+and (3Ca3 (PO4)2Ca(F, CI)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.

公开(公告)号：EP3134122A1

公开(公告)日：2017-03-01

申请号：EP15783728.7

申请日：2015-04-22

申请人： Immunolight, LLC. ,  Duke University ,  North Carolina State University

发明人： WALDER, Harold ,  BOURKE, Frederic, A. ,  FATHI, Zakaryae ,  BEYER, Wayne, F. ,  DEWHIRST, Mark, W. ,  OLDHAM, Mark ,  ADAMSON, Justus ,  NOLAN, Michael

IPC分类号： A61K41/00 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61N5/062 ,  A61K41/0042 ,  A61K41/0057 ,  A61K49/0423 ,  A61N5/1071 ,  A61N2005/1089 ,  A61N2005/1091 ,  A61N2005/1098

摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x- ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x- rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

摘要翻译： 介质内光刺激的系统和方法。 该系统具有被配置为从等于或低于200kVp的施加阴极施加电压产生X射线的降低电压x射线源，以及介质中的多个能量转换粒子，其在来自X射线源的辐射 以比x射线源低的能量辐射以与介质中的至少一种可光活化剂相互作用。 该方法将多个能量转换粒子引入到介质中，用从200kVp以下的施加阴极电压产生的x射线照射介质中的能量转换粒子; 并且发射比x射线源更低的能量以与介质或介质中的至少一种可光活化剂相互作用。

公开(公告)号：EP3630283A1

公开(公告)日：2020-04-08

申请号：EP18810795.7

申请日：2018-05-31

申请人： Immunolight, LLC ,  Duke University

发明人： BOURKE, Frederic A. ,  DEWHIRST, Mark ,  SPECTOR, Neil ,  YOON, Paul ,  ADAMSON, Justus ,  ALCORTA, David ,  LYERLY, Kim ,  LIU, Leihua ,  OSADA, Takuya ,  OLDHAM, Mark ,  FATHI, Zakaryae ,  BEYER, Wayne F. ,  WALDER, Harold

IPC分类号： A61N5/06 ,  A61B6/00 ,  A61K9/00 ,  A61K49/04 ,  A61N5/10

公开(公告)号：EP2729175A1

公开(公告)日：2014-05-14

申请号：EP12810688.7

申请日：2012-07-09

申请人： Duke University ,  Immunolight, LLC

发明人： BOURKE, Frederic, A. ,  WALDER, Harold ,  FATHI, Zakaryae ,  THERIEN, Michael J. ,  DEWHIRST, Mark W. ,  STANTON, Ian Nicholas ,  AYRES, Jennifer, Ann ,  FELS, Diane, Renee ,  HERBERT, Joseph, A.

IPC分类号： A61K41/00

CPC分类号： A61N5/062 ,  A61K41/0085 ,  A61N5/0622 ,  A61N5/1077 ,  A61N2005/0661 ,  A61N2005/1091 ,  A61N2005/1098

摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

公开(公告)号：EP2421376A1

公开(公告)日：2012-02-29

申请号：EP10767701.5

申请日：2010-04-21

申请人： Immunolight, Llc. ,  Duke University

发明人： VO-DINH, Tuan ,  SCAFFIDI, Jonathan P ,  CHADA, Venkata Gopal Reddy ,  LAULY, Benoit ,  ZHANG, Yan ,  GREGAS, Molly K. ,  STANTON, Ian Nicholas ,  STECHER, Joshua T. ,  THERIEN, Michael J. ,  AYRES, Jennifer ,  ZHANG, Zhenyuan ,  NORTON, Stephen John ,  BOURKE, Frederic A. ,  WALDER, Harold ,  FATHI, Zak ,  SIMMONS, Joseph H.

IPC分类号： A01N65/00

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength lambda1, to generate a second wavelength Iambda2 of radiation having a higher energy than the first wavelength lambda1. The methods may further be performed by application of an initiation energy to a subject in situ.

摘要翻译： 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由靶细胞，细胞，亚细胞结构介导或与之相关的疾病，病症或疾病 或胞外结构。 方法可以通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上并向受试者施加引发能量，从而产生一种 直接或通过调节剂影响或改变目标结构。 纳米颗粒在暴露于第一波长λ1时被配置以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。 该方法可以进一步通过将原始能量原位施用于受试者来进行，以直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激元活性剂的存在下产生影响或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：EP3367890A1

公开(公告)日：2018-09-05

申请号：EP16860690.3

申请日：2016-10-26

申请人： Immunolight, LLC. ,  Duke University

发明人： OLDHAM, Mark ,  ADAMSON, Justus ,  DEWHIRST, Mark, W. ,  YOON, Paul ,  WALDER, Harold ,  BOURKE, Frederic, A. ,  FATHI, Zakaryae ,  BEYER, Wayne, F.

IPC分类号： A61B5/00 ,  A61K33/02 ,  A61K41/00 ,  A61K49/04 ,  A61M36/02 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61K41/0066 ,  A61K31/352 ,  A61K31/403 ,  A61K31/409 ,  A61K31/426 ,  A61K31/47 ,  A61K31/525 ,  A61K31/655 ,  A61K33/02 ,  A61K33/24 ,  A61K2300/00 ,  A61N5/062 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/065 ,  A61N2005/1095 ,  A61N2005/1098 ,  B82Y5/00 ,  Y02A50/393

摘要： A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

公开(公告)号：EP3838904A1

公开(公告)日：2021-06-23

申请号：EP21154817.7

申请日：2015-06-18

申请人： Immunolight, LLC ,  Duke University

发明人： TOONE, Eric J. ,  GOODEN, David ,  BOURKE, Frederic A. ,  WALDER, Harold

IPC分类号： C07D493/04 ,  A61K31/37 ,  A61N5/06 ,  A61N5/10 ,  A61P35/00

摘要： Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D- 10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in Fig. 1, and pharmaceutically acceptable salts thereof; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an auto vaccine effect in a subject using the method.

公开(公告)号：EP3097108A2

公开(公告)日：2016-11-30

申请号：EP15740092.0

申请日：2015-01-23

申请人： Immunolight, LLC ,  Duke University ,  Xia, Wenle ,  Gooden, David ,  Soderblom, Erik, J. ,  Toone, Eric, J. ,  Spector, Neil, L. ,  Beyer, Wayne, F. ,  Walder, Harold

发明人： XIA, Wenle ,  GOODEN, David ,  SODERBLOM, Erik J. ,  TOONE, Eric J. ,  SPECTOR, Neil L. ,  BEYER, Wayne F. ,  WALDER, Harold

IPC分类号： C07D493/00

摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

摘要翻译： 用于治疗受试者的细胞增殖疾病或病症的方法，包括将缺乏DNA交联基序的补骨脂素衍生物施用于癌细胞，施用补骨脂素或其衍生物和拉帕替尼，或施用补骨脂素或其衍生物和神经痛素 ，并且进一步施加起始辐射能量形成能量源。

公开(公告)号：EP3097108B1

公开(公告)日：2020-11-04

申请号：EP15740092.0

申请日：2015-01-23

申请人： Immunolight, LLC ,  Duke University ,  Xia, Wenle ,  Gooden, David ,  Soderblom, Erik, J. ,  Toone, Eric, J. ,  Spector, Neil, L. ,  Beyer, Wayne, F. ,  Walder, Harold

发明人： XIA, Wenle ,  GOODEN, David ,  SODERBLOM, Erik J. ,  TOONE, Eric J. ,  SPECTOR, Neil L. ,  BEYER, Wayne F. ,  WALDER, Harold

IPC分类号： C07D493/00 ,  A61K45/06 ,  A61K41/00 ,  A61K31/517 ,  A61K31/4709 ,  A61K31/436 ,  A61K31/37 ,  A61P35/00

公开(公告)号：EP3365017A1

公开(公告)日：2018-08-29

申请号：EP16858126.2

申请日：2016-10-19

申请人： Immunolight, LLC ,  Duke University

发明人： FATHI, Zakaryae ,  BAYER, Wayne, F. ,  WALDER, Harold ,  BOURKE, Frederic, A. ,  OLDHAM, Mark ,  DEWHIRST, Mark ,  SPECTOR, Neil, L. ,  YOON, Paul ,  ADAMSON, Justus ,  ALCORTA, David ,  LYERLY, Kim ,  LIU, Leihua ,  OSADA, Takuya

IPC分类号： A61K41/00

CPC分类号： A61K41/0057 ,  A61K33/42 ,  A61K41/0066 ,  A61N5/00 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/1098

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.