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1.发明公开
公开(公告)号：EP3184526A1
公开(公告)日：2017-06-28
申请号：EP16197502.4
申请日：2006-12-12
发明人： RODGERS, James D. , SHEPARD, Stacey , MADUSKUIE, Thomas P. , WANG, Haisheng , FALAHATPISHEH, Nikoo , RAFALSKI, Maria , ARVANITIS, Argyrios G. , STORACE, Louis , JALLURI, Ravi Kumar , FRIDMAN, Jordan S. , VADDI, Krishna
IPC分类号： C07D471/04 , C07D487/04 , A61K31/395 , A61P17/00 , A61P35/00 , A61P37/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides deuterated derivatives of the compounds
These derivatives modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.摘要翻译： 本发明提供化合物的氘化衍生物。这些衍生物调节Janus激酶的活性，并用于治疗与Janus激酶活性有关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增殖性疾病，癌症， 和其他疾病。
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公开(公告)号：EP3184526B1
公开(公告)日：2018-10-03
申请号：EP16197502.4
申请日：2006-12-12
发明人： RODGERS, James D. , SHEPARD, Stacey , MADUSKUIE, Thomas P. , WANG, Haisheng , FALAHATPISHEH, Nikoo , RAFALSKI, Maria , ARVANITIS, Argyrios G. , STORACE, Louis , JALLURI, Ravi Kumar , FRIDMAN, Jordan S. , VADDI, Krishna
IPC分类号： C07D471/04 , C07D487/04 , A61K31/395 , A61P17/00 , A61P35/00 , A61P37/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K31/573 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines (I) and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
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3.发明公开JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES 审中-公开JANUS激酶抑制剂用于治疗干眼症和其他眼部相关疾病
公开(公告)号：EP3042655A1
公开(公告)日：2016-07-13
申请号：EP15195683.6
申请日：2009-10-01
IPC分类号： A61K31/437 , A61K31/519 , A61P27/00
CPC分类号： A61K31/519 , A61K9/0048 , A61K31/437
摘要： Methods, kits, and compositions for treating dry eye disorders and other related eye diseases are provided, wherein the methods, kits, and compositions utilize a JAK inhibitor.
摘要翻译： 提供了用于治疗干眼症和其他相关眼病的方法，试剂盒和组合物，其中所述方法，试剂盒和组合物利用JAK抑制剂。
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4.发明授权JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES 有权Janus激酶抑制剂干眼症的治疗和其他眼病
公开(公告)号：EP2349260B1
公开(公告)日：2016-01-06
申请号：EP09737257.7
申请日：2009-10-01
IPC分类号： A61K31/437 , A61K31/519 , A61P27/00
CPC分类号： A61K31/519 , A61K9/0048 , A61K31/437
摘要： Methods, kits, and compositions for treating dry eye disorders and other related eye diseases are provided, wherein the methods, kits, and compositions utilize a JAK inhibitor.
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公开(公告)号：EP3466953A1
公开(公告)日：2019-04-10
申请号：EP18191992.9
申请日：2006-12-12
发明人： RODGERS, James D. , SHEPARD, Stacey , MADUSKUIE, Thomas P. , WANG, Haisheng , FALAHATPISHEH, Nikoo , RAFALSKI, Maria , ARVANITIS, Argyrios G. , STORACE, Louis , JALLURI, Ravi Kuma , FRIDMAN, Jordan S. , VADDI, Krishna
IPC分类号： C07D487/04 , A61K31/395 , A61P17/00 , A61P35/00 , A61P37/00
摘要： The present invention provides the use of 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile in the preparation of a medicament for use in the treatment of graft versus host disease.
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