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公开(公告)号：EP2044079A1
公开(公告)日：2009-04-08
申请号：EP07786063.3
申请日：2007-07-13
申请人： Indena S.p.A.
IPC分类号： C07D491/22 , A61K31/4745 , A61P35/00
CPC分类号： C07D491/22
摘要： 5-Substituted thio-camptothecin derivatives having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
摘要翻译： 具有抗肿瘤活性的5-取代硫代喜树碱衍生物，其制备方法，其作为抗肿瘤药物的用途以及含有它们的药物组合物。
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公开(公告)号：EP1737855A1
公开(公告)日：2007-01-03
申请号：EP05715662.2
申请日：2005-03-02
申请人： Indena S.P.A.
发明人： FONTANA, Gabriele , BOMBARDELLI, Ezio , SAMORI, Cristian , BALDELLI, Eleonora , GUERRINI, Andrea , BATTAGLIA, Arturo , DANIELI, Bruno
IPC分类号： C07D459/00
CPC分类号： C07D459/00
摘要： The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
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公开(公告)号：EP2044079B1
公开(公告)日：2015-12-09
申请号：EP07786063.3
申请日：2007-07-13
申请人： Indena S.p.A.
IPC分类号： C07D491/22 , A61K31/4745 , A61P35/00
CPC分类号： C07D491/22
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公开(公告)号：EP2044078A1
公开(公告)日：2009-04-08
申请号：EP07786046.8
申请日：2007-07-12
申请人： Indena S.p.A.
IPC分类号： C07D491/20 , A61K31/4745 , A61P35/00
CPC分类号： Y02P20/55
摘要： Novel camptothecin derivatives of Formula (I) having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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公开(公告)号：EP1737855B1
公开(公告)日：2008-06-25
申请号：EP05715662.2
申请日：2005-03-02
申请人： Indena S.P.A.
发明人： FONTANA, Gabriele , BOMBARDELLI, Ezio , SAMORI, Cristian , BALDELLI, Eleonora , GUERRINI, Andrea , BATTAGLIA, Arturo , DANIELI, Bruno
IPC分类号： C07D459/00
CPC分类号： C07D459/00
摘要： The present invention relates to an efficient procedure for the synthesis of deserpidine (Ia), starting from reserpic acid lactone (II) via the intermediate 11-O-demethyl reserpic acid lactone (III).
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公开(公告)号：EP2044080B1
公开(公告)日：2017-05-10
申请号：EP07786096.3
申请日：2007-07-16
申请人： Indena S.p.A.
IPC分类号： C07D491/22 , A61K31/4745 , A61P35/00
CPC分类号： C07D491/22
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公开(公告)号：EP2044078B1
公开(公告)日：2010-09-22
申请号：EP07786046.8
申请日：2007-07-12
申请人： Indena S.p.A.
IPC分类号： C07D491/20 , A61K31/4745 , A61P35/00
CPC分类号： Y02P20/55
摘要： Novel camptothecin derivatives of Formula (I) having antitumor activity, the processes for the preparation thereof, the use thereof as antitumor drugs and pharmaceutical compositions containing them.
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8.发明授权
公开(公告)号：EP1423108B1
公开(公告)日：2007-06-06
申请号：EP02764753.6
申请日：2002-07-23
申请人： INDENA S.p.A.
IPC分类号： A61K31/337 , A61P35/00 , C07D305/14 , C07D407/12 , C07D409/12
CPC分类号： C07D407/12 , C07D305/14
摘要： Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R1 is t-butoxycarbonyl or benzoyl; R¿2? is hydroxy; R3 is hydrogen or, together with R2, it forms the residue of a cyclic carbonate of formula: I I with the proviso that when R3 is hydrogen, R is different from phenyl.Compounds of formula (I) have antitumor activity.
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9.发明公开
公开(公告)号：EP1423108A1
公开(公告)日：2004-06-02
申请号：EP02764753.6
申请日：2002-07-23
申请人： INDENA S.p.A.
IPC分类号： A61K31/337 , A61P35/00 , C07D305/14 , C07D407/12 , C07D409/12
CPC分类号： C07D407/12 , C07D305/14
摘要： Taxane derivatives of formula (I) in which: R is trifluoromethyl, phenyl, 2-furyl, 2-thienyl; R1 is t-butoxycarbonyl or benzoyl; R¿2? is hydroxy; R3 is hydrogen or, together with R2, it forms the residue of a cyclic carbonate of formula: I I with the proviso that when R3 is hydrogen, R is different from phenyl.Compounds of formula (I) have antitumor activity.
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