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17 条记录 (耗时 0.02 秒)

    NITROSATED AND NITROSYLATED ALPHA-ADRENERGIC RECEPTOR ANTAGONISTS, COMPOSITIONS AND METHODS OF USE
    5.
    发明公开
    NITROSATED AND NITROSYLATED ALPHA-ADRENERGIC RECEPTOR ANTAGONISTS, COMPOSITIONS AND METHODS OF USE 审中-公开
    NITRO和α-肾上腺素能受体，SETS方法和用途镀锌亚硝拮抗剂

    公开(公告)号：EP1109542A1

    公开(公告)日：2001-06-27

    申请号：EP99944040.7

    申请日：1999-09-01

    申请人： Nitromed, Inc.

    发明人： GARVEY, David, S. ,  SCHROEDER, Joseph, D. ,  SAENZ DE TEJADA, Inigo ,  GASTON, Ricky, D. ,  SHELEKHIN, Tatiana, E. ,  WANG, Tiansheng

    IPC分类号： A61K31/13 ,  A61K31/195 ,  A61K31/415

    CPC分类号： C07D459/00 ,  A61K45/06 ,  C07C381/00 ,  C07D211/62 ,  C07D233/24 ,  C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  Y10S514/929 ,  Y10S514/968

    摘要： The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

    Nitrosated and nitorsylated alpha-andrenergic receptor antagonist compounds, compositions and their uses
    8.
    发明公开
    Nitrosated and nitorsylated alpha-andrenergic receptor antagonist compounds, compositions and their uses 失效
    亚硝化和亚硝基化andrenergische的α-受体拮抗剂化合物，它们的组合物，及其用途

    公开(公告)号：EP1852422A2

    公开(公告)日：2007-11-07

    申请号：EP07011814.6

    申请日：1997-01-28

    申请人： Nitromed, Inc.

    发明人： Garvey, David S. ,  Schroeder, Joseph, D. ,  Saenz de Tejada, Inigo

    IPC分类号： C07D233/20 ,  A61K31/4164 ,  A61P15/10

    CPC分类号： C07D459/00 ,  C07C381/00 ,  C07D211/62 ,  C07D233/24 ,  C07D239/95 ,  C07D401/04 ,  C07D405/12 ,  Y10S514/929

    摘要： Disclosed are nitrosated and nitrosylated α-adrenergic receptor antagonists, compositions of an α-adrenergic receptor antagonist (α-antagonist), which can optionally be substituted with at least one NO or NO 2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO + ) or nitroxyl (NO - ), or as the neutral species, nitric oxide (NO.); and uses for each of them in treating human impotence or erectile dysfunction.

    摘要翻译： 本发明公开了亚硝化和亚硝酰化±肾上腺素能受体拮抗剂，一个±肾上腺素能受体拮抗剂的组合物（±拮抗剂），其可以与至少一种的NO或NO 2基团的化合物，以及任选地被substituiertem做捐赠，转移或释放一 氧化物作为带电物质，即，亚硝鎓（NO +）或硝酰基（NO - ），或作为中性物质，一氧化氮（NO）; 并在治疗人类阳痿或勃起功能障碍的用途为他们每个人。