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公开(公告)号：EP2376521B1
公开(公告)日：2016-04-13
申请号：EP09837985.2
申请日：2009-12-18
IPC分类号： C07K14/62 , C07K14/625 , A61K38/28 , A61K47/48
CPC分类号： C07K14/622 , A61K38/28 , A61K47/48246 , A61K47/64 , C07K14/62 , C07K14/625
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公开(公告)号：EP2376521A1
公开(公告)日：2011-10-19
申请号：EP09837985.2
申请日：2009-12-18
IPC分类号： C07K1/00
CPC分类号： C07K14/622 , A61K38/28 , A61K47/48246 , A61K47/64 , C07K14/62 , C07K14/625
摘要： Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
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公开(公告)号：EP2585102A2
公开(公告)日：2013-05-01
申请号：EP11798912.9
申请日：2011-06-23
IPC分类号： A61K38/28
摘要： Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
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