公开(公告)号：EP2320233A1

公开(公告)日：2011-05-11

申请号：EP10182027.2

申请日：2002-06-17

申请人： Inhibitex, Inc. ,  The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin ,  Universita' Degli Studi Di Pavia

发明人： Foster, Timothy J. ,  Roche, Fiona ,  Patti, Joseph M. ,  Hutchins, Jeff T. ,  Speziale, Pietro ,  Pallen, Mark

IPC分类号： G01N33/569 ,  C07K16/00 ,  C07K16/12 ,  C07K14/31 ,  A61K39/40

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. (hemolyticus), are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. (aureus) and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供哪些是交叉反应性的，以两个凝固酶阳性的葡萄球菌细菌，：如对（溶血性）多克隆和单克隆抗体可以从两个凝固酶阳性和凝固酶阴性葡萄球菌细菌识别表面蛋白。 从表面蛋白thathave被分离特性的基础上，可以产生的抗体做了用于产生本发明的抗体S.（金黄色葡萄球菌）和凝固酶阴性葡萄球菌，和合成的重组表面蛋白之间可能是共同的。 因此，提供了疫苗和其利用合成蛋白质和抗体用于抗多种葡萄球菌感染的治疗或保护方法。

公开(公告)号：EP1423701B1

公开(公告)日：2012-07-25

申请号：EP02756219.8

申请日：2002-06-17

申请人： Inhibitex, Inc. ,  The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin ,  Universita' Degli Studi Di Pavia

发明人： Foster, Timothy J. ,  Roche, Fiona, c/o The Provost Fellows & Scholars ,  Patti, Joseph M. ,  Hutchins, Jeff T. ,  Speziale, Pietro ,  Pallen, Mark

IPC分类号： C07K16/12 ,  C07K14/31 ,  G01N33/569 ,  A61K39/40

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

公开(公告)号：EP2339344A1

公开(公告)日：2011-06-29

申请号：EP10182270.8

申请日：2002-06-17

申请人： Inhibitex, Inc. ,  The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin ,  Universita' Degli Studi Di Pavia

发明人： Foster, Timothy J. ,  Roche, Fiona ,  Patti, Joseph M. ,  Hutchins, Jeff T. ,  Speziale Pietro ,  Pallen, Mark

IPC分类号： G01N33/569 ,  C12N5/16 ,  C07K16/00 ,  C07K16/12 ,  C07K14/31 ,  A61K39/40

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. (hemolyticus), are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. (aureus) and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

摘要翻译： 提供哪些是交叉反应性的，以两个凝固酶阳性的葡萄球菌细菌，：如对（溶血性）多克隆和单克隆抗体可以从两个凝固酶阳性和凝固酶阴性葡萄球菌细菌识别表面蛋白。 从表面蛋白thathave被分离特性的基础上，可以产生的抗体做了用于产生本发明的抗体S.（金黄色葡萄球菌）和凝固酶阴性葡萄球菌，和合成的重组表面蛋白之间可能是共同的。 因此，提供了疫苗和其利用合成蛋白质和抗体用于抗多种葡萄球菌感染的治疗或保护方法。