公开(公告)号：EP1423701B1

公开(公告)日：2012-07-25

申请号：EP02756219.8

申请日：2002-06-17

申请人： Inhibitex, Inc. ,  The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin ,  Universita' Degli Studi Di Pavia

发明人： Foster, Timothy J. ,  Roche, Fiona, c/o The Provost Fellows & Scholars ,  Patti, Joseph M. ,  Hutchins, Jeff T. ,  Speziale, Pietro ,  Pallen, Mark

IPC分类号： C07K16/12 ,  C07K14/31 ,  G01N33/569 ,  A61K39/40

CPC分类号： C07K16/1271

摘要： Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. hemolyticus, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.