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1.发明授权METHYLATED, SmD HOMOLOGOUS PEPTIDES, REACTIVE WITH THE ANTIBODIES FROM SERA OF LIVING BEINGS AFFECTED WITH SYSTEMIC LUPUS ERYTHEMATOSUS 有权甲基化SMD同源性肽的抗体从众生的血清与系统性红斑狼疮REACT
公开(公告)号：EP0944649B1
公开(公告)日：2006-10-18
申请号：EP98947487.9
申请日：1998-08-31
申请人： Innogenetics N.V.
IPC分类号： C07K14/705 , C07K16/18 , C07K16/42 , G01N33/564 , C12N15/12 , C12P21/02 , A61K38/17
CPC分类号： C07K7/08 , A61K38/00 , C07K14/001 , C07K14/4713 , C07K14/525 , C07K2319/00
摘要： The present invention relates to a method of producing certain peptides containing methylated arginines that are followed by a glycine residue and that constitute immunogenic determinants of antibodies present in sera from patients with systemic lupus erythematosus, or Epstein-Barr virus and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said peptides for diagnosis and treatment of systemic lupus erythematosus and related diseases, and diseases in which Epstein-Barr virus has been implicated.
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2.发明公开SYNTHETIC PEPTIDES CONTAINING CITRULLINE RECOGNIZED BY RHEUMATOID ARTHRITIS SERA AS TOOLS FOR DIAGNOSIS AND TREATMENT 审中-公开瓜氨酸，含有合成肽，活性的血清风湿关节炎患者，诊断和治疗
公开(公告)号：EP1034186A2
公开(公告)日：2000-09-13
申请号：EP98965715.0
申请日：1998-11-30
申请人： INNOGENETICS N.V.
发明人： MEHEUS, Lydie , UNION, Ann , RAYMACKERS, Joseph
IPC分类号： C07K14/47 , C07K1/107 , C07K16/18 , A61K38/17 , G01N33/564
CPC分类号： C07K1/107 , A61K38/00 , C07K14/4713 , C07K2319/00
摘要： The present invention relates to a method of producing certain peptides containing citrulline residues that constitute immunogenic determinants of antibodies present in sera from patients with rheumatoid arthritis and wherein the presence of at least one citrulline is a prerequisite for reacting with said antibodies. The invention also relates to a method of producing said antibodies and the use of said peptides for diagnosis and treatment of rheumatoid arthritis.
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3.发明公开METHYLATED, SmD HOMOLOGOUS PEPTIDES, REACTIVE WITH THE ANTIBODIES FROM SERA OF LIVING BEINGS AFFECTED WITH SYSTEMIC LUPUS ERYTHEMATOSUS 有权甲基化SMD同源性肽的抗体从众生的血清与系统性红斑狼疮REACT
公开(公告)号：EP0944649A1
公开(公告)日：1999-09-29
申请号：EP98947487.0
申请日：1998-08-31
申请人： INNOGENETICS N.V.
IPC分类号： G01N33 , A61K38 , A61K39 , A61P29 , A61P35 , A61P37 , C07K7 , C07K14 , C07K16 , C12N15 , C12P21 , C12R1
CPC分类号： C07K7/08 , A61K38/00 , C07K14/001 , C07K14/4713 , C07K14/525 , C07K2319/00
摘要： The present invention relates to a method of producing certain peptides containing methylated arginines that are followed by a glycine residue and that constitute immunogenic determinants of antibodies present in sera from patients with systemic lupus erythematosus, or Epstein-Barr virus and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said peptides for diagnosis and treatment of systemic lupus erythematosus and related diseases, and diseases in which Epstein-Barr virus has been implicated.
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