公开(公告)号：EP2234624B1

公开(公告)日：2018-06-20

申请号：EP09707528.7

申请日：2009-01-12

申请人： Inovio Pharmaceuticals, Inc.

发明人： RAMANATHAN, Mathura, P. ,  SARDESAI, Niranjan, Y.

IPC分类号： A61K31/70 ,  C12P19/34 ,  C12N7/01 ,  A61K39/295

CPC分类号： A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/394

摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.

公开(公告)号：EP3909973A3

公开(公告)日：2022-01-26

申请号：EP21175561.6

申请日：2011-11-14

申请人： The Trustees of The University of Pennsylvania ,  Inovio Pharmaceuticals, Inc.

发明人： WEINER, David, B. ,  YAN, Jian ,  FERRARO, Bernadette ,  SARDESAI, Niranjan, Y. ,  RAMANATHAN, Mathura, P.

IPC分类号： C07K14/47 ,  A61K39/00

摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.

公开(公告)号：EP3909973A2

公开(公告)日：2021-11-17

申请号：EP21175561.6

申请日：2011-11-14

申请人： The Trustees of The University of Pennsylvania ,  Inovio Pharmaceuticals, Inc.

发明人： WEINER, David, B. ,  YAN, Jian ,  FERRARO, Bernadette ,  SARDESAI, Niranjan, Y. ,  RAMANATHAN, Mathura, P.

IPC分类号： C07K14/47 ,  A61K39/00

摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.