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1.发明授权SHIGA TOXIN B-SUBUNIT AS A VECTOR FOR TUMOR DIAGNOSIS AND DRUG DELIVERY TO GB3-EXPRESSING TUMORS 有权志贺毒素-B亚单位作为载体肿瘤诊断和ARZNEIMTTELVERABREICHUNG TO GB3表达TUMORS-
公开(公告)号：EP1525478B1
公开(公告)日：2009-08-12
申请号：EP03775133.6
申请日：2003-07-31
申请人： Institut Curie , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI)
发明人： JOHANNES, Ludger , FLORENT, Jean-Claude , GRIERSON, David , MAILLARD, Philippe , ROBINE, Sylvie , ROGER, Jacky
IPC分类号： G01N33/574
CPC分类号： A61K49/085 , A61K38/00 , A61K41/0071 , A61K47/6415 , A61K47/67 , A61K49/0008 , A61K49/14 , B82Y5/00 , C07K14/25 , C07K14/36
摘要： The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)- T wherein - STxB is the Shiga Toxin B subunit or a functional equivalent thereof, - Z(n) wehrein n is 0 or 1 and when n is 1, Z is an amino-acid residue devoidof sulfydryl group, or is a polypeptide, - Cys is the amino-acid residue for Cysteine, - T is a molecule linked by a covalent bound to the S part of Cys, selected in a group comprising: . agents for in vivo diagnosis, . cytotoxic agents, . prodrugs, or . enzymes for the conversion of a prodrug to a drug, - Y(m) wherein m is 0 or 1 and when m is 1, Y is a linker between T and Cys, said linker being either cleavable or not cleavable for the release of T after the internalization of the hybrid compound into said cells.
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2.发明公开NOVEL DIBENZO[c,h][1,5]NAPHTHYRIDINES AND THEIR USE AS DNA PROBES 有权NEW二苯并[c，H] [1,5]萘啶和它们作为DNA探针使用
公开(公告)号：EP1991546A1
公开(公告)日：2008-11-19
申请号：EP07705594.5
申请日：2007-02-15
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Institut Curie , Centre National de la Recherche Scientifique , COMMISSARIAT A L'ENERGIE ATOMIQUE
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , Y10T436/143333
摘要： The present invention concerns novel dibenzo[c,h] [1, 5]naphthyridine of formula (I) and their use as DNA probes, as well as the methods for marking DNA using the same .
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3.发明公开
公开(公告)号：EP1684750A2
公开(公告)日：2006-08-02
申请号：EP04791783.6
申请日：2004-10-22
发明人： MOUSSY, Alain , WERMUTH, Camille , GRIERSON, David , BENJAHAD, Abdellah , CROISY, Martine , CIUFOLINI, Marco , GIETHLEN, Bruno
IPC分类号： A61K31/422
CPC分类号： C07D263/48 , C07D413/04 , C07D413/14 , E21B33/038 , E21B43/121
摘要： The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
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4.发明公开
公开(公告)号：EP3536691A1
公开(公告)日：2019-09-11
申请号：EP19164367.5
申请日：2009-01-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , Institut Curie , UNIVERSITE DE MONTPELLIER
IPC分类号： C07D401/12 , C07D213/74 , A61K31/444 , C07D401/14
摘要： The present invention relates to specific compounds; pharmaceutical composition comprising at least one of said compounds; and the use of at least one of said compounds in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.
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5.发明公开CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES 审中-公开化学分子为疾病的治疗由拼接条件剪接机制的抑制剂
公开(公告)号：EP2235000A2
公开(公告)日：2010-10-06
申请号：EP09700499.8
申请日：2009-01-12
申请人： Centre National de la Recherche Scientifique (CNRS) , Institut Curie , Université Montpellier 2 Sciences et Techniques
IPC分类号： C07D401/12 , C07D213/74 , A61K31/444 , A61K31/4439 , A61K31/4192 , A61P25/00 , A61P35/00 , A61P17/00 , A61P9/10 , A61P7/12 , A61P3/10 , A61P31/18 , A61K31/165 , A61K31/415 , A61K31/472 , C07D213/81
CPC分类号： A61K31/166 , A61K31/417 , A61K31/4192 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/4725 , C07C237/30 , C07D213/38 , C07D213/56 , C07D213/74 , C07D213/75 , C07D213/82 , C07D233/61 , C07D233/64 , C07D249/06 , C07D401/12 , C07D401/14
摘要： The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.
摘要翻译： 本发明涉及式I至XXI中的一个的化合物; 一种药物组合物，其包括测试至少一种化合物; 和在制备药物以治疗，在受试者中使用的至少一种试验化合物，一种遗传性疾病由至少一种剪接异常所致。
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6.发明授权DERIVES D'INDOLE POUR LE TRAITEMENT DE MALADIES LIEES AU PROCESSUS D'EPISSAGE 有权化合物由吲哚用于生产药物用于疾病治疗剪接过程相关的使用
公开(公告)号：EP1663219B1
公开(公告)日：2010-05-12
申请号：EP04787316.1
申请日：2004-09-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite Montpellier 2 Sciences Et Techniques , Institut Curie
发明人： TAZI, Jamal , SORET, Johann , JEANTEUR, Philippe , GRIERSON, David , RIVALLE, Christian , BISAGNI, Emile , NGUYEN, Chi Hung
IPC分类号： A61K31/437 , A61K31/403
CPC分类号： A61K31/4375 , A61K31/403 , A61K31/437 , A61K31/4745 , A61K31/496 , A61K31/5377 , C07D209/80 , C07D471/04 , C07D471/14
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7.发明授权
公开(公告)号：EP1318995B1
公开(公告)日：2006-03-08
申请号：EP01980812.0
申请日：2001-09-18
发明人： GUILLEMONT, Jérôme , BENJAHAD, Abdellah , MABIRE, Dominique , N'GUYEN, Chi, Hung , GRIERSON, David , MONNERET, Claude , BISAGNI, Emile , SANZ, Gérard , DECRANE, Laurence
IPC分类号： C07D401/12 , C07D213/78 , C07D407/06 , C07D417/06 , C07D401/06 , C07D213/71 , C07D405/04 , C07D213/82 , C07D213/70 , C07D213/69 , C07D409/12 , C07D417/12 , C07D405/12 , C07D491/04 , C07D215/22
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D213/78 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89 , C07D215/22 , C07D215/227 , C07D215/36 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D407/12 , C07D407/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/04
摘要： The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C1-6 alkyl or C2-6 alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R1 is aryl; R2 is selected from formyl; C1-6alkyloxycarbonylalkyl; Het?2; Het2C¿1-6alkyl, C1-6alkylthio; C1-6alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R3 is selected from formyl; C1-6alkyl optionally substituted with one or two C1-6alkyloxy; R4 is hydrogen, with HIV inhibiting properties.
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8.发明授权NOUVEAUX COMPOSÉS DÉRIVÉS D'INDOLE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT 有权新INDOLDERIVATVERBINDUNGEN和药物组合物含
公开(公告)号：EP2121685B1
公开(公告)日：2016-02-17
申请号：EP08716957.9
申请日：2008-02-19
申请人： Centre National de la Recherche Scientifique (CNRS) , Institut Curie , Université de Montpellier
发明人： LEJEUNE, Fabrice , TAZI, Jamal , GRIERSON, David , RIVALLE, Christian , MAHUTEAU-BETZER, Florence
IPC分类号： C07D471/04 , C07D401/12
CPC分类号： C07D471/14 , C07D401/12 , C07D471/04
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公开(公告)号：EP2340249B1
公开(公告)日：2013-09-11
申请号：EP09756849.7
申请日：2009-11-02
申请人： Institut Curie , Centre National de la Recherche Scientifique (CNRS) , Institut National De La Sante Et De La Recherche Medicale , Museum National D'histoire Naturelle (MNHN)
发明人： NGUYEN, Chi-Hung , ROUCHON DAGOIS, Myriam , GUEDIN-BEAUREPAIRE, Aurore , MONCHAUD, David , TEULADE-FICHOU, Marie-Paule , RIOU, Jean-François , MERGNY, Jean-Louis , GRIERSON, David
IPC分类号： C07D413/14 , A61K31/444 , A61P35/00 , A61K31/4439 , A61K31/496
CPC分类号： C07D413/14 , Y10T436/143333
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公开(公告)号：EP2340249A1
公开(公告)日：2011-07-06
申请号：EP09756849.7
申请日：2009-11-02
申请人： Institut Curie , Centre National de la Recherche Scientifique (CNRS) , Institut National De La Sante Et De La Recherche Medicale , Museum National D'histoire Naturelle (MNHN)
发明人： NGUYEN, Chi-Hung , ROUCHON DAGOIS, Myriam , GUEDIN-BEAUREPAIRE, Aurore , MONCHAUD, David , TEULADE-FICHOU, Marie-Paule , RIOU, Jean-François , MERGNY, Jean-Louis , GRIERSON, David
IPC分类号： C07D413/14 , A61K31/444 , A61P35/00 , A61K31/4439 , A61K31/496
CPC分类号： C07D413/14 , Y10T436/143333
摘要： The present invention relates to Penta- hexa-, hepta-, octa-, nona- and, deca-heteroaryl derivatives, comprising a combination of heterocycle 1 (Het-1)
a and/or heterocycie 2 (Het-2)
b and/ or heterocycle 3 (Het-3)
c and/or heterocycle 4 (Het-4)
d of formulae I, II, III and IV respectively, the N-oxides, the pharmaceutically acceptable addition salts. The compounds claimed are suitable for the treatment of cancer.
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