公开(公告)号：EP2938353A1

公开(公告)日：2015-11-04

申请号：EP13831825.8

申请日：2013-12-26

申请人： Institut National de la Recherche Agronomique (INRA)

发明人： LANGELLA Philippe ,  PIGNEUR-ARNAUD, Bénédicte. ,  CHATEL, Jean-Marc. ,  TRUGNAN, Germain. ,  QUEVRAIN, Elodie. ,  SENSIK, Philippe. ,  BERMUDEZ-HUMARAN, Luis G. ,  CHAIN, Florian. ,  MAUBERT, Marie-Anne. ,  SOKOL, Harry. ,  MICHON, Christophe.

IPC分类号： A61K38/16

CPC分类号： A61K38/164 ,  A61K35/74 ,  C07K14/195

摘要： The present invention relates to a polypeptide comprising or consisting of the amino acid sequence SEQ ID NO:1, for use in the treatment or prevention of an inflammatory disease. The invention further encompasses a nucleic acid sequence encoding a polypeptide of the invention, a vector comprising a nucleic acid of the invention and a host cell comprising a nucleic acid sequence and/or a vector of the invention, for use in the treatment or prevention of an inflammatory disease. The invention also concerns a pharmaceutical composition comprising a polypeptide, a nucleic acid sequence, a vector or a host cell of the invention and a pharmaceutically acceptable carrier, for the treatment of inflammatory disease.

公开(公告)号：EP2938353B1

公开(公告)日：2018-08-15

申请号：EP13831825.8

申请日：2013-12-26

申请人： Institut National de la Recherche Agronomique (INRA)

发明人： LANGELLA Philippe ,  PIGNEUR-ARNAUD, Bénédicte ,  CHATEL, Jean-Marc ,  TRUGNAN, Germain ,  QUEVRAIN, Elodie ,  SEKSIK, Philippe ,  BERMUDEZ-HUMARAN, Luis G. ,  CHAIN, Florian ,  MAUBERT, Marie-Anne ,  SOKOL, Harry ,  MICHON, Christophe

IPC分类号： A61K38/16

CPC分类号： A61K38/164 ,  A61K35/74 ,  C07K14/195

摘要： The present invention relates to a polypeptide comprising or consisting of the amino acid sequence SEQ ID NO:1, for use in the treatment or prevention of an inflammatory disease. The invention further encompasses a nucleic acid sequence encoding a polypeptide of the invention, a vector comprising a nucleic acid of the invention and a host cell comprising a nucleic acid sequence and/or a vector of the invention, for use in the treatment or prevention of an inflammatory disease. The invention also concerns a pharmaceutical composition comprising a polypeptide, a nucleic acid sequence, a vector or a host cell of the invention and a pharmaceutically acceptable carrier, for the treatment of inflammatory disease.

公开(公告)号：EP3177306A1

公开(公告)日：2017-06-14

申请号：EP15750388.9

申请日：2015-08-10

申请人： Institut National de la Recherche Agronomique (INRA) ,  MUSEUM NATIONAL D'HISTOIRE NATURELLE ,  Ecole Nationale Vétérinaire D'Alfort

发明人： BERMUDEZ-HUMARAN, Luis G. ,  ALLAIN, Thibault ,  FLORENT, Isabelle ,  LANGELLA, Philippe ,  GRELLIER, Philippe ,  TRAVERS, Marie-Agnès ,  POLACK, Bruno

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/46 ,  A61K35/74 ,  A61P33/02 ,  C07K14/335 ,  C12N15/74 ,  A61K35/741 ,  A61K35/744

CPC分类号： A61K38/50 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/03 ,  A23Y2220/37 ,  A23Y2220/43 ,  A61K35/741 ,  A61K35/744 ,  A61K38/00 ,  A61K38/164 ,  A61K38/46 ,  C12N9/80 ,  C12Y305/01024 ,  Y02A50/491

摘要： The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

摘要翻译： 本发明涉及显示胆盐水解酶活性的组合物用于治疗或预防贾第虫病，所述组合物包含胆盐水解酶（BSH）酶，能够分泌BSH的细菌，重组宿主 细胞能够分泌BSH或其组合。 本发明还涉及显示BSH活性的组合物用于治疗或预防贾第虫病的用途，并且涉及包含作为活性成分的BSH，能够分泌乳酸菌的药物组合物或食物组合物 BSH或能够分泌BSH的重组宿主细胞。